摘要
目的分析乙肝患者使用拉米夫定抗病毒治疗后早期应答反应对耐药的预测。方法对服用拉米夫定抗病毒治疗的门诊乙肝患者200例进行回顾分析。结果服药后4、12、24周HBV-DNA下降<103cp/ml的患者和HBV-DNA下降幅度大(>3log10cp/ml)的患者,HBV-DNA回升耐药率低。结论可根据服药后12周HBV-DNA下降的速度和幅度情况,来预测乙肝患者耐药的发生率,更好的指导临床用药。
Objective To iavestigate the effects of the early response predict Io drug resistance in chronic hepatitis B （CHB） patients with lamivudine（LAM） antiviral therapy. Methods Retrospective analysis two hundrand LAM-treated CHB patients in out-patient clinic. Results HBV-DNA rebound rate is lower in the patient with HBV-DNA levels 〈 10^3 cp/ml and as same as in tile patient with HBV-DNA lcvels decrease 〉 3log10cp/ml after Lamivudine treatment 4 weeks 12 weeks 24 weeks. Conclusion The speed and the extent of HBV-DNA decreased levels in 12 weeks can predict incidence rate of lamivudine resistance and better guide the use of clinical medication.
出处
《四川医学》
CAS
2008年第6期656-657,共2页
Sichuan Medical Journal
关键词
乙型肝炎
拉米夫定
抗病毒治疗
早期应答
耐药
type B hepatitis
lamivudine
antiviral therapy
early respond
drug resistance
作者简介
通讯作者
