摘要
应用细胞培养技术,将获取的小鼠腹腔巨噬细胞用浓度为0mg/L、1mg/L、10mg/L、20mg/L 的含氟溶液进行培养,以观察氟对巨噬细胞分泌的白细胞介素—1(IL—1)和肿瘤坏死因子(TNFα)的影响。结果显示:含氟1mg/L 的溶液明显抑制 IL—1的活性;三种含氟溶液对 TNFα均显示明显的抑制作用,并随浓度增高,抑制作用增强。提示氟可抑制 IL—1和 TNFα的活性。
In order to investigate the effect of fluoride on the activity of interleukin-1(IL-1)and tumour necrosis factor(TNFα)secreted by macrophage,the peritoneal macrophage in mice incubated with fluo- ride at dosage of 0 mgF^-/L,lmgF^-/L,10mgF^-/L,and 20mgF^-/L.The results showed that the activity of IL-1 didn't markedly decrease at the concentration of 1mgF^-/L,but activity of IL-1 decreased sig- nificantly at the dosage of 10mgF^-/L and 20mgF^-/L.The activity of TNFα decreased significantly with the increase of fluoride concentration.It suggested that fluoride could inhibit the activity of 1L-1 and TNFα.
出处
《中国地方病学杂志》
CAS
CSCD
1997年第5期274-275,共2页
Chinese Jouranl of Endemiology
