摘要
骨质疏松(OP)是炎症性肠病(IBD)患者常见但易被忽视的并发症之一。IBD患者骨代谢异常的发病机制除了营养不良,钙、磷吸收异常,性腺功能减退之外,还与使用激素,炎症因子的异常活化等紧密相关。研究发现IBD患者骨质疏松发生率在15%左右,在老年IBD患者身上表现尤为显著,使用激素是其主要危险因子。IBD患者骨折发生率并没有原先预期的那么高。骨代谢指标对预测IBD患者BMD及骨折发生价值有限。
Osteoporosis is one of the complications of inflammatory bowel disease（IBD）, which is easy to be ignored. Except for corticosteroid use and the activation of pro-inflammatory cytokines, the pathogenesis of IBD-induced osteoporosis includes malnutrition, calcium and phosphonium malabsorption, hypoganadism et al. The prevalence of osteoporosis in inflammatory bowel disease is about 15%, with osteoporosis more common in older subjects. The main risk factor is corticosteroid use . The overall incidence of fractures in inflammatory bowel disease is not higher than expected. Biochemical bone markers do not correlate sufficiently well with current BMD or rate of bone loss.
出处
《国际消化病杂志》
CAS
2008年第3期217-219,共3页
International Journal of Digestive Diseases
关键词
炎症性肠病
骨质疏松
发病率
骨折风险
Inflammatory
Bowel disease
Osteoporosis
Prevalence
Fracture risk
