摘要
目的评价葛根素对不稳定型心绞痛的临床疗效。方法将70例不稳定型心绞痛患者随机分为两组,均常规口服阿司匹林、血管紧张素转化酶抑制剂类药物、受体阻滞剂、他汀类药物等。心绞痛发作时舌下含服硝酸甘油。治疗组加用葛根素注射液500 mg/d,对照组加用复方丹参注射液30 ml/d,两组均连续使用14 d,观察心绞痛的发作、心电图的变化及血液流变学变化指标。结果两周后心绞痛缓解,总有效率对照组为74.29%,治疗组为91.43%,差异有统计学意义(P<0.05);心电图疗效比较:治疗组心肌缺血改善的总有效率为94.29%,对照组为77.14%,差异有统计学意义(P<0.05);血液流变学比较:治疗组全血粘度、血浆粘度及纤维蛋白原、红细胞比容均有明显改善(P<0.05),而对照组无此作用。结论葛根素能有效改善不稳定型心绞痛患者的症状,抗心肌缺血,降低血液粘度。
Objective To evaluate the efficacy of puerain in treating unstable angina pectoris.Methods Seventy unstable annina pectoris patients were randomly divided into two groups.Both of the groups＇patients were given aspirin,ACEI（beta-adrenergic blocking agent） and statins.However,sublingual nitroglycerin was treated in patients with argina pectoris happening.The treatment group were given puerarin injection-500 mg iv drip qd.And patients in the control group were given compound root of red rooted salvia injection 30 ml iv drip qd.Before and 14 days after the treatment.All treatment effect,the alteration of ECG and the index sign of hemorheology were recorded.Results The respective total clinical effective rate of the treatment group and the control group were 91.43% and 74.29%,there were significant differences between the two groups（P〈0.05）.The respective total electrocardiogram effective rate of the treatment group and the control group were 94.29% and 77.14%.There had significcant differences too.The index sign of hemorheology iucluding viscosity of blood and plasma,fibrinogen hematocrit（HCT） decreased remarkably in treatment group.However it was not used in control treatment.Conclusion Puerarin can improve the unstable angina pectoris patients＇dlinical symptoms effectively.Puerarin can decrease blood and plasma zpecitic viscosity.
出处
《临床医学》
CAS
2008年第6期3-4,共2页
Clinical Medicine
关键词
葛根素
复方丹参注射液
不稳定型心绞痛
Puerarin
Root of red rooted salvia injection
Unstable angina pectoris
