摘要
目的评价布拉酵母菌治疗儿童急性腹泻的疗效及安全性。方法采用多中心、随机、对照研究方法。对象为儿科门诊年龄在1个月～8岁之间、病程在48 h内、镜下大便白细胞<10个/HP、未使用任何抗腹泻治疗方法的急性腹泻患儿共137例,随机分组分别给予布拉酵母菌或双八面体蒙托石口服,治疗5 d后判断疗效。结果共有134例完成本试验,治疗后48 h大便好转率双八面体蒙托石组为69.35%,布拉酵母菌组为84.00%;治疗后72 h愈合率双八面体蒙托石组为53.22%,布拉酵母菌组为60.00%;患儿平均止泻时间双八面体蒙托石组约3.58 d,布拉酵母菌组为3.12 d;病程在7 d以内的患儿比率均超过85%;两组患儿的止泻时间和腹泻病程差异无统计学意义。所有病例未发生明显不良反应或过敏反应。结论布拉酵母菌治疗急性腹泻的疗效等同于双八面体蒙托石,且无任何不良反应发生,布拉酵母菌作为治疗腹泻病的新型药物,可于临床应用。
Objectives To evaluate the efficacy and safety of in Saccharormyces boulardil the treatment of acute diarrhea in children. Methods A multi-center, randomized and controlled trial was conducted in 137 children aged from 1 month to 8 years. None of the children treated with antibiotics, had mild to moderate diarrhea of less than 48 hours duration, and white blood cells in stool less than 10 per high power field. They were randomly assigned to receive Saccharomyces boulardii （S. boulardii group） or dioctahedral smectite （control group）. Frequency and consistency of stools as well as safety of drug were assessed 48 hours and 72 hours after treatment. Results 134 children were enrolled. The improvement rate of diarrhea after 48 hours was 84.00% in S. boulardii group and 69.35% in control group （P = 0.041 ）, the improvement rates were 60.00% and 53.22%, respectively, after 72 hours （P = 0.425）. The duration of diarrhea was 3.12 days in S. boulardii group whereas it was 3.58 days in control group （P = 0.080）. The risk of diarrhea lasting 〈 7 days was more than 85% in two groups （P = 0.347）. There was no difference in the duration of diarrhea between two groups. Side effects or allergic reactions were not seen in either group. Conclusions Saccharomyces boulardii was as effective as dioctahedral smectite for the treatment of acute diarrhea without side effects. As a new drug for diarrhea, Saccharomyces boulardil might benefit children with diarrhea and should be used more widely in clinical practice.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2008年第6期528-531,共4页
Journal of Clinical Pediatrics
关键词
布拉酵母菌
急性腹泻
儿童
Saccharomyces boulardii
acute diarrhea
children
