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穿破石对四氯化碳致小鼠急性肝损伤的保护作用 被引量：1

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摘要 细胞色素P450（cytchrome P450，CYP450）是一类参与内源性和外源性化合物代谢的酶。由CYP450酶系作用的药物生物转化是药物代谢的重要环节,同时许多药物又对CYP450酶系活性有抑制或诱导作用，也是四氯化碳（CCl4）在体内进行代谢活化的主要酶类。
作者 吴奕富
机构地区 福建中医学院药学系
出处 《福建中医学院学报》 2008年第3期30-32,共3页 Journal of Fujian College of Traditional Chinese Medicine
关键词 穿破石 四氯化碳 肝微粒体 自由基
分类号 R285.5 [医药卫生—中药学]
作者简介 吴奕富（1966-），男，实验师，主要从事中药炮制研究。
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参考文献7

二级参考文献20

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  • 2[1] Chaudhury S, Mehendale HM. Amplification of CCl4 toxicity by chlordecone: Destruction of rat Hepatic microsomal cytochrome P-450 subpopulation, J Toxicol Environ Health, 1991, 32:277-294.
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共引文献100

同被引文献20

  • 1吴黎莉,张尊建,许风国,田媛,陈沄.黄芩苷胶囊的人体生物等效性研究[J].中国新药与临床杂志,2005,24(9):687-690. 被引量：8
  • 2Gao N,Qi B,Liu F J,et al.Inhibition of baicalin on metabolism of phenacetin,a probe of CYP1A2,in human liver microsomes and in rats[J].PLo S One,2014,9(2):e89752.
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  • 4Men L,Zhao Y,Lin H,et al.Characterization of in vitro metabolites of TM-2,a potential antitumor drug,in rat,dog and humanliver microsomes using liquid chromatography/tandem mass spectrometry[J].Rapid Commun Mass Spectrom,2014,28(20):2162-2170.
  • 5Li M,Shi A,Pang H,et al.Safety,tolerability,and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects[J].J Ethnopharmacol,2014,156(1):210-215.
  • 6Gao N,Fang Y,Qi B,et al.Pharmacokinetic changes of unbound theophylline are due to plasma protein binding displacement and CYP1A2 activity inhibition by baicalin in rats[J].J Ethnopharmacol,2013,150(2):477-484.
  • 7Tian X,Cheng Z Y,He J,et al.Concentration-dependent inhibitory effects of baicalin on the metabolism of dextromethorphan,a dual probe of CYP2D and CYP3A in rats[J].Chem Biol Interact,2013,203(2):522-529.
  • 8Gao N,Zou D,Qiao H L.Concentration-dependent inhibitory effect of baicalin on the plasma protein binding and metabolism of chlorzoxazone,a CYP2E1 probe substrate,in rats in vitro and in vivo[J].PLo S One,2013,8(1):e53038.
  • 9康杰芳,任婷婷.中药黄芩的研究进展[J].陕西农业科学,2009,55(4):128-131. 被引量：27
  • 10林庆辉,庄笑梅,邓婧婷,韩刚,宫泽辉,李桦.罗通定和羟考酮体外代谢的相互作用[J].中国药理学与毒理学杂志,2009,23(5):404-410. 被引量：9

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福建中医学院学报
2008年 第3期

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