摘要
脑红蛋白（neuroglobin,Ngb）是携氧球蛋白家族成员之一，主要以单体形式存在于神经细胞中，与脑内氧供应密切相关。脑缺血缺氧能诱导Ngb高表达，并作为一种内源性神经保护因子保护神经元免受缺血缺氧性损害。文章对Ngb的分布、结构、功能及其在缺血缺氧性脑损伤中的保护作用和机制做了综述。
Neuroglobin （Ngb） is one of the members of oxygen-carrying globin family. It mainly exists in neurons in a monomeric form, which is closely correlated the oxygen supply to brain. Brain hypoxia/ischemia can induce the high expression of Ngb, and as an endogenous neuroprotective factor, it protects ischemic neurons from ischemia/hypoxia injury, This article reviews the distribution, structure and function of Ngb, and its potential protective effects and mechanisms in cerebral ischemia/hypoxia cerebral injury.
出处
《国际脑血管病杂志》
2008年第5期380-383,共4页
International Journal of Cerebrovascular Diseases
基金
河北省自然科学基金（C2006000915）
关键词
脑红蛋白
缺血缺氧
神经保护
neuroglobin
hypoxia/ischemia
brain injury
neruroprotection
