摘要
目的观察哮喘患者急性发作期、缓解期的肺功能和血嗜酸粒细胞(EOS)的变化,探讨其临床意义。方法测定57例急性发作期哮喘患者肺功能,并取外周血进行EOS计数,经治疗后选取符合缓解期标准患者50例,也进行肺功能测定和外周血EOS计数,比较两期患者肺功能及EOS测定结果。结果急性发作期哮喘患者外周血EOS明显高于缓解期患者(P<0.01),肺功能FEV1明显低于缓解期患者(P<0.05),EOS与FEV1和50%及25%用力肺活量时呼气流速(V50、V25)呈显著负相关(P<0.05)。结论外周血ESO在哮喘急性发作时明显增加,提示EOS是反映气道炎症程度的可靠指标。反映小气道功能的V50、V25在急性发作期与缓解期变化不大,多数患者在缓解期仍存在小气道功能异常,提示缓解期气道炎症仍持续存在,需要进行长期的维持治疗。
Objective It is to observe the changes of lung function and eosinophil （EOS） in patients with bronchia asthma in acute-outbreak period and catabatic period, so to explore its clinical significance, Methods Lung function of 57 patients with asthma in acute-outbreak was detected, and the patients＇ EOS in peripheral blood were counted, After treatment, 50 patients according with the standard of catabatic period were chosen from the patients above and accepted the same examination, The detecting results of lung function and EOS counts between the patients in different stage were compared, Results The counts of EOS in peripheral blood were significantly higher in patients with asthma in acute-outbreak period than that in patients in catabatic period （P 〈 0,01 ）, but FEV1 in the former patients was obviously lower than that in the latter patients （P 〈 0,05）. EOS, FEV1, V50 and V25 were minus related（ P 〈 0.05）, Conclusion EOS in peripheral blood increases when asthma breakouts, EOS is a reliable index that reflects the grades of trachea inflammation, V50 and V25 which represent the functions of small trachea don＇t change much in both the two periods, Majority of the patients still have abnormal small trachea function which indicates that trachea inflammation remains and needs long maintenane therapy.
出处
《现代中西医结合杂志》
CAS
2008年第19期2932-2933,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
哮喘
血嗜酸粒细胞
肺功能
气道炎症
急性发作期
缓解期
asthma
eosinophil
lung function
trachea inflammation
acute-outbreak period
catabatic period
作者简介
杨美艳，女，副主任医师，主要从事呼吸内科临床诊治工作。
