期刊文献+

麻黄碱对支气管平滑肌细胞增殖的影响 被引量:22

The influences of ephedrine on proliferation of bronchial smooth muscle cells
在线阅读 下载PDF
导出
摘要 在前人工作的基础上,采用一种更简省的方法分离培养支气管平滑肌细胞;并且利用显微镜观察和MTT的方法,研究了麻黄碱对支气管平滑肌细胞形态和增殖的影响。结果表明:麻黄碱对支气管平滑肌细胞的形态没有明显影响,但是对平滑肌细胞的增殖有一定的抑制作用,并进一步阐述了麻黄碱治疗哮喘等呼吸系统疾病的作用机理。 On the basis of research work previously, a more convenient and economical method was used to isolate the bronchial smooth muscle cells (BSMCs). By means of microscope observation and MTT methods, the effects of ephedrine on appearance and proliferation of BSMCs were studied. Results showed that ephedrine had no obvious influences on the morph of BSMCs, but ephedrine inhibited the proliferation of BSMCs. The further progress to elucidate the mechanism of ephedrine treated on asthma and other diseases of respiratory apparatus was made.
出处 《生物学杂志》 CAS CSCD 2008年第3期27-29,共3页 Journal of Biology
关键词 麻黄碱 哮喘 细胞增殖 ephedrine asthma cell proliferation
作者简介 景红娟,女,博士在读,主要从事动物电生理和离子通道方面的研究。
  • 相关文献

参考文献9

  • 1Emilia M, Manuela P, Roberta P, et al. A rapid and simple procedure for the determination of ephedrine alkaloids in dietary supplements by gas chromatography-mass spectrometry[J]. Journal of pharmaceutical and biomedical analysis, 2006, 2 : 1 - 9.
  • 2刘先胜,徐永健,张珍祥,倪望,陈仕新.蛋白激酶C对大鼠支气管平滑肌K_V通道的影响[J].生理学报,2003,55(2):135-141. 被引量:17
  • 3Hutchinson K, Andrews K M. The use and availability of ephedra products in the United States[J]. Microgram, 1995, 28 (8) : 256 - 263.
  • 4Reinoud G, Johan Z, Mechteld G B, et al. Acetylcholine: a novel regulator of airway smooth muscle remodelling? [ J ]. European Journal of Pharmacology, 2004,500 : 193 - 201.
  • 5Barnes P J, Chung K F, Page C P. Inflammatory mediators of asthma: an update[J]. Pharmacol. Rev, 1998, 50:515-596.
  • 6Jeffery P K. Remodeling in asthma and chronic obstructive lung disease[J]. Am J Respir Crit Care Med, 2001,164, 28S-38S.
  • 7Stewart A G, Bonacci J V, Quan L. Factors controlling airway smooth muscle proliferation in asthma [ J ]. Curr Allergy Asthma Rep, 2004 ,4:109-115.
  • 8Krymskaya V P, Orsini M J, Eszterhas A J, et al. Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein - coupled receptor activation in human airway smooth muscle [ J ]. Am J Respir Cell Mol Biol, 2000, 23:546 -554.
  • 9Gosens R, Nelemans S A, Grootte Bromhaar M M, et al. Muscarinic M3 - receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle[J]. Am J Respir Cell Mol Biol, 2003,28:257 -262.

二级参考文献1

  • 1林枫译.克隆化基因所表达蛋白质的检测与分析[A].金冬雁 黎孟枫主译.分子克隆[C].北京:科学技术出版社,1992.852—898.

共引文献16

同被引文献309

引证文献22

二级引证文献263

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部