摘要
目的：了解亚胺培南耐药菌株的分离情况、耐药性和流行分布。方法：2000年1月至2006年12月,收集该院临床各类标本中分离的耐亚胺培南菌株934株,采用V itek-32型微生物自动分析仪,对菌株进行鉴定及药敏试验。结果：该院亚胺培南耐药菌株的分离率从2000年的0-3.15%上升至2006年的18.9%-33.1%。其中非发酵菌占97.6%,以铜绿假单胞菌最多,占60.6%（553/912）;其次是鲍曼不动杆菌,占28.5%（260/912）。最常见的感染部位是呼吸系统,痰、咽拭子等呼吸道标本的分离率最高,占76.7%,其他依次为脓性分泌物、体液、血液、尿液和导管等。耐亚胺培南的菌株对其他常用抗菌药物的耐药率均较高（35%-100%）,其中以鲍曼不动杆菌对头胞哌酮/舒巴坦的耐药率最低（35%）。结论：耐亚胺培南菌株大多存在多重耐药性,甚至泛耐性,应根据药敏试验的结果选用敏感的抗菌药物进行治疗。
Objective： To investigate the isolation,distribution and drug-resistance of Imipenem-resistant strains. Methods： Totally 934 Imipenem-resistant strains were isolated from various specimens collected from January 2000 to December 2006 and the Vitek-32 system was applied to bacteriaL identification and susceptibility testing. Results：The isolation rates were increased from 0 -3.15% in 2000 to 18.9% -33.1% in 2006. Among the 934 strains, 97.6% were nonfermentative bacilli. P. aeruginosa and A. baumannii accounted for 60. 6% （553/912）and 28.5% （260/912）, respectively, with the highest isolation rate, 76.7%, in the specimens from the respiratory tract. The susceptibility tests showed that these strains were muhiresistant to commonly used antibiotics, with high resistance rates from 35% to 100%. Cefoperazone/sulbactam was the most active antibiotic against A. baumannii with the lowest resistance rate of 35%. Conclusion： Imipenem-resistant strains were mostly multi-drug resistant, even pan-drug resistant. Different antimicrobial therapy should be adopted according to the results of susceptibility tests.
出处
《医学研究生学报》
CAS
2008年第5期464-467,共4页
Journal of Medical Postgraduates
基金
江苏省医学重点学科基金资助项目(批准号:苏卫科教[2001]34)
作者简介
史利宁（1973-）。女，江苏南京人，主管技师，医学硕士，从事临床微生物检验专业。
