摘要
目的探讨猪慢性胰腺炎（CP）MR灌注加权成像（PWI）表现。方法从28头猪中，以数字表法随机抽取22头经剖腹行胰管结扎制作CP动物模型，另外6头不进行处理。麻醉后行MRPWI，检查后随即处死动物，根据胰腺组织病理检查结果，将实验猪分为胰腺正常组、CPⅠ期组、CPⅡ期组和CPⅢ期组。采用方差分析法比较各组间胰腺最大灌注斜率、达峰时间和最大强化率，并采用相关性分析法判定各灌注参数与CP严重程度的关系。结果21头猪进行了MR PWI检查，其中胰腺正常组7头、CPⅠ期组7头、CPⅡ期组3头和CPⅢ期组4头。胰腺正常组、CPⅠ期组、CPⅡ期组和CPⅢ期组最大灌注斜率分别为（10．88±1．20）％、（10．59±1．02）％、（6．67±1．31）％和（5．48±1．97）％，差异有统计学意义（F=20．51，P〈0．05）；达峰时间分别为（13．82±3．09）s、（12．31±5．52）s、（20．55±3．79）s和（37．26±14．56）s，差异有统计学意义（F=10．68，P〈0．05）；最大强化率分别为（62．95±20．20）％、（60．44±20．00）％、（46．33±22．70）％和（67．65±32．66）％，差异无统计学意义（F=0．53，P〉0．05）。最大灌注斜率（r=0．72，P〈0．05）和达峰时间（r=0．54，P〈0．05）与CP严重程度间具有相关性；CP严重程度与最大强化率间无明显线性关系。结论MRPWI可以检测猪CP改变，并可对其进行分期。
Objective To characterize pancreatic perfusion in swines with experimental chronic pancreatitis （CP） by dynamic contrast-enhanced MRI and to correlate it with the severity of CP. Methods Twenty-two swines were randomly selected and made CP by ligation of main pancreatic duct. Six healthy swines served as control. MR perfusion study with dynamic contrast-enhanced MRI was carried out on the swines under anesthesia. The animals were euthanized after MR perfusion exam. The swines were divided into 4 groups according to the histological results of pancreas ： normal group, group of CP of grade 1, group of CP of grade 2, and group of CP of grade 3. The maximum perfusion slope rate, the time-to-peak value and the maximum enhancement rate was compared between the groups using variance analysis, and the relationship between each perfusion parameters and severity of CP was made by correlative analysis. Results Twenty-one swines underwent MR perfusion study, including 7 swines in normal group, 7 in group of grade 1 CP, 3 in group of grade 2 CP, and 4 in group of grade 3 CP. On signal intensity time curve（SI-T） derived from MR perfusion weighted imaging, the maximum slope rate was（ 10. 88 ± 1.20）% , （ 10. 59 ± 1.02）% , （6. 67± 1.31 ）%, and（5.48 ± 1.97）% for normal swines, swines with grade 1 CP, swines with grade 2 CP and swines with grade 3 CP, respectively（ F=20. 51, P 〈 0. 05 ）. The time-to-peak value was（ 13.82 ±3.09）s,（12.31±5.52）s,（20.55 ±3.79）s and（37.26 ± 14.56）s respectively （F=10.68,P〈0.05）. The maximal signal enhancement rate was （ 62. 95 ± 20. 20 ） % , （ 60. 44 ± 20. 00 ） % , （ 46. 33 ± 22. 70 ） % , and（67. 65± 32. 66 ） % , respectively （ F = 0. 53, P 〉 0. 05 ）. The highest slope value （ r = - 0. 72, P 〈 0. 05 ） and the time-to-peak （ r = 0.54, P 〈 0. 05 ） of the SI-T curve were correlated to the severity of CP, respectively. However there was no linear correlation between the maximal signal enhancement rate and the severity of CP. Conclusion MR perfusion weighted imaging has a potential to diagnose and to grade experimental chronic pancreatitis.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2008年第5期527-530,共4页
Chinese Journal of Radiology
基金
四川省青年基金资助项目（03ZQ026-048）
教育部新世纪优秀人才支持计划资助项目（NCET-06-0820）
关键词
胰腺炎
慢性
磁共振成像
灌流
猪
Pancreatitis,chronic
Magnetic resonance imaging
Perfusion
Swine
作者简介
通信作者：张小明，Email：cjr．zhxm@vip．163．com
