摘要
成纤维细胞生长因子-21（FGF-21）是成纤维细胞家族成员之一，其受体可能为FGFR-1和FGFR-2，与受体的结合可能需要βKlotho，过氧化物酶体增殖物活化受体（PPAR）α对FGF-21的分泌起重要的调节作用。FGF-21可通过蛋白激酶B（Akt）信号转导途径抵抗细胞因子和糖脂毒性诱导的β细胞凋亡，通过非胰岛素信号依赖通路降低血糖，并且能改善脂代谢、刺激胰岛素分泌，且与PPARγ信号转导途径存在相互协同作用，显示出潜在的糖尿病治疗作用。
Fibroblast growth factor-21, whose receptor may be fibroblast growth factor receptor-1 （ FGFR-1 ） and FGFR-2, is one member of the FGF family. β Klotho is needed when FGF-21 binds to its receptors. PPARα is a key regulator of FGF-21. FGF-21 directly inhibits apoptosis of β-cells induced by eytokine and glucose/lipid toxicity through activation of the Akt signaling pathway. Furthermore, FGF-21 decreases glucose by insulin-independent pathway. Moreover, it improves lipid metabolism and stimulates insulin secretion. In addition, there exists a novel synergy between FGF-21 and PPARγ. FGF-21 demonstrates potential therapeutic effect of diabetes.
出处
《国际内分泌代谢杂志》
2008年第3期174-176,共3页
International Journal of Endocrinology and Metabolism
作者简介
通讯作者：安振梅，Email：anzm1997@sina．com
