摘要
目的比较2型糖尿病患者合并急性冠状动脉综合征时应用两种不同胰岛素给药方法的治疗效果。方法将住院治疗的168例合并急性冠状动脉综合征的2型糖尿病患者随机分为两组,胰岛素皮下连续注射法治疗组(CSII组)与胰岛素多次皮下注射法组(MSII组)。两组患者年龄、糖尿病病程、血糖、治疗方式相比无显著性差异,分析低血糖及主要心脏不良事件发生率(室速室颤、心衰、心源性死亡)。结果CSII组的血糖达标时间、低血糖(血糖低于3.0mmol/L)和主要心脏不良事件发生率均低于MSII组。结论胰岛素泵模拟胰岛素的生理分泌模式,能更有效地控制高血糖,并减少糖尿病患者合并急性冠状动脉综合征时主要心脏不良事件发生率。
Objective To compare the efficacy of two different ways of insulin delivery in treating type 2 diabetic patients with acute coronary syndromes.Methods One hundred and Sixty-eight type 2 diabetic patients with acute coronary syndromes were randomly divided into two groups,Continuous subcutaneous insulin injection treatment group（CSII）and multiple subcutaneous insulin injection treatment group（MSII）.Patients in two groups were matched in age、course of diabetes、blood glucose and treatment of acute coronary syndromes.Hypoglycemia and the risk of major adverse cardiac events（ventricular tachycardia and fibrillation,heart failure and cardiac death）were analyzed.Results The time of blood glycose control and the rate of hypoglycemia and major adverse cardiac events in CSII group were less than those in the control group.Conclusion Insulin pump simulated physiological pattern of insulin secretion may be more effective to control hyperglycemia and reduce the incidence of major adverse cardiac events in type 2 diabetic patients with acute coronary syndromes.
出处
《临床内科杂志》
CAS
2008年第4期266-267,共2页
Journal of Clinical Internal Medicine
关键词
胰岛素输注系统
糖尿病
冠状动脉疾病
Insulin infusion systems
Diabetic mellitus
Coronary disease
