摘要
目的:研究玄参科婆婆纳属植物水蔓菁(Veronica linariifolia Pall. ex Link subsp. dilatata(Nakai et Kitagawa)Hong)中的酚性化学成分。方法:采用75%乙醇提取,运用各种色谱方法进行化学成分的分离纯化,用理化方法及波谱手段解析其化学结构。结果:分离并鉴定了14个酚性化合物,其中黄酮类7个,分别为3′,4′,5,6,7-五羟基黄酮-7-O-β-D-葡萄糖基-(1″→2′)-β-D-葡萄糖苷(Ⅰ)、4′,5,7-三羟基-3′,6-二甲氧基黄酮-7-O-β-D-葡萄糖苷(Ⅱ)、芹菜素-7-O-β-D-葡萄糖醛酸苷甲酯(Ⅲ)、芹菜素-7-O-β-D-葡萄糖醛酸苷乙酯(Ⅳ)、芹菜素-7-O-β-D-葡萄糖醛酸苷丁酯(Ⅴ)、芹菜素(Ⅵ)、木犀草素(Ⅶ);酚酸类5个,分别为香草酸(Ⅷ)、对羟基苯甲酸(Ⅸ)、原儿茶酸(Ⅹ)、原儿茶酸乙酯(Ⅺ)、异阿魏酸(Ⅻ),还分到儿茶酚(X)、大黄素(XⅣ)。结论:除化合物Ⅵ、Ⅶ外,其余均为在该植物中首次分得,其中化合物Ⅱ～Ⅴ、Ⅺ、X、X为该属植物中首次分得。
AIM： To investigate the chemical constituents of Veronica linariifolia Pall. ex Link subsp, dilatata （Nakai et Kitagawa ） Hong. METHODS： Extracted with 75 % alcohol, isolated by column chromatography on silica Gel, and purified by recrystallization. RESULTS： Fourteen phenolic compounds were isolated from Veronica linariifolia. On the basis of the physical properties and spectral data, the structures were identified as 3＇, 4＇, 5, 6, 7-pentahydroxyflavone-7-O-β-D-glucosyl-（ 1″→2′）-β- D-glucoside （ Ⅰ）, 4＇, 5, 7-trihydroxy-3＇, 6-dimethoxyflavone-7-O-β-D-glucoside （Ⅱ）, apigenin-7-O-β-D-glucuronide methyl ester （ Ⅲ）, apigenin-7-O-β-D-glucuronide ethyl ester （Ⅳ）, apigenin-7-O-β-D-glucuronide buthyl ester （ Ⅴ）, apigenin（Ⅵ）, luteolin （Ⅶ）, vanillic acid （Ⅷ）, p-hydroxybenzoic acid（Ⅸ）, protocatechuic acid （Ⅹ）, protocatechuic acid ethyl esler （Ⅺ）, isnerulic acid （Ⅻ）, catechol （ⅫⅠ） and emodin （ⅩⅣ）. CONCLUSION： Except for apigenin and lutelin, the other twelve compounds were obtianed from this plant for the first time, and compounds Ⅱ- Ⅴ, Ⅻ, ⅩⅣ, were obtianed from genus Veronica for the first time.
出处
《中国天然药物》
SCIE
CAS
CSCD
2008年第2期126-129,共4页
关键词
婆婆纳属
水蔓菁
酚性成分
Veronica
Veronica linariifolia
Phenolic constituents
作者简介
【通讯作者】秦民坚：教授，博导，Tel：025—85391290，E—mail：minjianqin@sina．com.
