摘要
用ＲＴ－ＰＣＲ检测１９例急性白血病和６例多发性骨髓瘤患者ＭＤＲ１和ＭＲＰ表达水平。结果显示：临床耐药患者ＭＤＲ１表达水平明显增高；与临床耐药之间呈显著正相关（ｒ＝０．６１２，Ｐ＜０．０１）；与ＭＲＰ之间无明显相关性（ｒ＝０．０３５，Ｐ＞０．０５）。表明ＭＤＲ１是临床耐药的主要机制。
RT PCR method was used to detect the expression level of multi drug resistance gene (MDR 1) and multi drug resistance associated protein (MRP) in patients with malignant blood disease, including 19 cases of acute leukemia and 6 cases of multiple myeloma. The results showed: expression level of MDR 1 in patients with known clinical drug resistance elevated obviously and was significantly associated with clinical drug resistance (r=0.612, P<0.01), which indicated that expression of MDR 1 was the main mechanism of clinical drug resistance. There is no obvious relationship between expression level of MDR 1 and MRP (r=0.035,P>0.05).
出处
《湖南医科大学学报》
CSCD
1997年第4期344-346,共3页
Bulletin of Hunan Medical University
关键词
白血病
多发性骨髓瘤
耐药基因
耐药相关蛋白
leukemia
multiple myeloma
multi drug resistance *
gene
multi drug resistance associated protein
