摘要
水解α-甲基-ω-（2，3-环氧）丙基聚乙二醇（Ⅱ）得到接有聚乙二醇（PEG）枝的丙二醇（Ⅲ），用其与对苯二甲酰氯及聚丁二醇反应制得在硬链段接有PEG枝的聚醚聚酯（H－PEEs）．以四氢呋喃与Ⅱ进行正离子开环共聚合制得每个链接有1．25个PEG枝的聚丁二醇（Ⅳ），用Ⅳ合成了在软链段上接PEG枝的聚醚聚酯（S－PEEs）．不同位置接技的PEEs亲水性均较母体明显改进，抗凝血性则以H－PEEs改进显著，其抗凝血复钙时间比本接技者约增长1倍，而S－PEEs改进不明显．
α-Methyl-ω-(2, 3-epoxy)propyl poly (ethylene glycol) (Ⅱ) was hydrolyzed to a glycol (Ⅲ) with a pendent poly (ethylene glycol ) (PEG) chaln. Poly (ether-ester) (PEEs )with PEG grafted ont0 the hard segments (H-PEEs) was synthesized by reacting the glycol (Ⅲ), terephthaloyl chloride and poly (butylene glycol ) The macromer (Ⅱ) cationically copolymerized with tetrahydrofuran to give a copolyether (Ⅳ ) grafted with PEG. Using copolyether(Ⅳ ) having an average 1. 25 grafts per molecule, the S-PEEs with PEG grafted onto soft segments was synthesized. The recalcification time for SuPEEs remalned almost unchanged in comparing with ungrafted PEEs, while that for HuPEEs increased by about 1O0%, even though the hydrophlcillties both of S-PEEs and H-EEs were ralsed slgniflcantly.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1997年第3期477-480,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
关键词
聚醚聚酯
接枝共聚物
抗凝血性
PEEs
H-PEEs
poly (ether-ester), Macromer,Ring-opening copolymerization,Graft copolymer,Antithrombogenicity
