摘要
目的:研究密花豆藤(Spatholobus suberectu)、白花油麻藤(Mucuna bird woodiana)、皱果崖豆藤(Millettia oosperma)、香花崖豆藤(Millettia dielsiana)等4种同名异种鸡血藤对骨髓抑制小鼠外周血象的作用。方法:60Coγ射线亚致死量辐照造成骨髓抑制小鼠模型,灌胃给药,于给药后1、3、7、14和21d监测其外周血白细胞、红细胞和血小板计数。结果:给予同名异种鸡血藤治疗后,小鼠外周血白细胞、红细胞和血小板计数下降趋势减缓,与对照组比较,白花油麻藤和密花豆藤高、低剂量组的白细胞、红细胞和血小板计数升高,差异有统计学意义(P<0.05)。结论:同名异种鸡血藤均可在一定程度上促进辐射小鼠外周血象的恢复,其中密花豆藤和白花油麻藤作用相对较好。
Objective： To investigate the effects of heterogenous suberect spatholobus stem （Spatholobus suberectu, Mucuna birdwoodiana, Millettia oosperma and Millettia dielsiana） on peripheral blood cell counts of mice with bone marrow suppression induced by 60Co γ ray irradiation.Methods： Bone marrow suppression was induced by sublethal dose of 60Co γ ray in mice. White blood cell （WBC）, red blood cell （RBC） and platelet （PLT） counts in peripheral blood of the mice were detected one day, 3, 7, 14 and 21 days after intragastric administration of different doses of the four kinds of suberect spatholobus stem, respectively.Results： A slowdown of the decrease of WBC, RBC and PLT counts in peripheral blood of the mice with bone marrow suppression was observed after intragastric administration. The WBC, RBC and PLT counts in the Mucuna birdwoodiana-treated and Spatholobus suberectu-treated groups were significantly higher than those in the untreated group （P〈0.05）.Conclusion： All the four kinds of heterogenous suberect spatholobus stem can accelerate the recovery of WBC, RBC and PLT counts in peripheral blood of mice with bone marrow suppression, while the effects of Spatholobus suberectu and Mucuna birdwoodiana are relatively good.
出处
《中西医结合学报》
CAS
2007年第2期189-192,共4页
Journal of Chinese Integrative Medicine
基金
国家自然科学基金资助项目(No30500650)
关键词
鸡血藤
白细胞
红细胞
血小板
小鼠
suberect spatholobus stem
leukocytes
erythrocytes
blood platelets
mice
作者简介
Correspondence：Dong-Xiao WANG，MD．Assoclate Professor；Tel：010-68234090；E-mail：haixia0301@163.com
