摘要
目的评价小剂量奥美拉唑治疗功能性消化不良(FD)的疗效。方法将2005年9月至2007年9月在辽宁省人民医院消化内科门诊就诊的260例FD患者随机分为2组,口服小剂量奥美拉唑148例(观察组),口服埃索美拉唑和多潘立酮共112例(对照组)。疗程均为2周。观察两组患者胃部烧灼感、餐后饱胀、上腹痛及嗳气等症状改善程度。结果两组治疗前后胃部烧灼感、上腹痛症状评分下降差异均有统计学意义(P<0.01);嗳气症状评分下降差异有统计学意义(P<0.05);餐后饱胀症状分级评分对照组治疗前后差异有统计学意义(P<0.05)。上述症状评分治疗后两组比较,差异均无统计学意义(P>0.05)。结论小剂量奥美拉唑治疗FD疗效肯定,与埃索美拉唑和多潘立酮联合用药效果相近,而且用药不良反应少,可作为治疗FD首选用药。
Objective To evaluate the effect of low-dose omeprazole in the treatment of functional dyspepsia（FD）. Meth. ods A total of 260 FD patients were diagnosed clearly and divided into two groups randomly： 148 cases （observation group）were treated with low-dose omeprazole（ 10 mg/d） ,while 112 cases（ control group）were treated with esomeprazole （20 mg/d）and domperidone （each 10 mg, three times per day）. Two groups were all treated for 2 weeks. The clinical symptoms such as heartburn, postprandial distenstion, epigastric pain and eructation were observed. Results Compared with symptoms in two groups before treatment,the scores of heartburn and epigastric pain were decreased evidently after treatment in two groups（ P 〈0. 01 ）and the score of eructation also had a decrease（ P 〈0. 05 ）, The score of postprandial distenstion in control group after treatment was lower than pre-treatment （ P 〈 0. 05 ）. Total remission rate of observation group had no difference from that of control group（78. 3% vs 80, 3% ）. Conclusion The effect of low-dose omeprazole in the treatment of FD is similar to the effect of esomeprazole and domperidone. And few adverse reactions was observed, Omeprazole can be used as first choice drug in treating FD.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2008年第3期211-212,共2页
Chinese Journal of Practical Internal Medicine
作者简介
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