摘要
天然CD4+CD25+调节T细胞来源于胸腺,通过直接接触机制抑制效应细胞的增殖,调节自身免疫和移植免疫。本文主要综述了影响天然调节T细胞分化、发育和功能的主要因素和可能机制。Foxp3是Treg的标志,检测其表达可以作为判定Treg的方法。IL-2主要通过IL-2Rα及STAT5途径促进Treg的增殖活化。膜型和分泌型TGF-β具有不同功能,膜型TGF-β1可能主要介导Treg的抑制功能,而分泌型TGF-β可能主要促进Treg的增殖。树突状细胞由于作用途径不同,对Treg既有正调节,也有负调节。CTLA-4途径可能通过作用于Treg自身、DC或效应细胞直接或间接地调节Treg的功能。
Naturally occurred CD4 ^＋ CD25 ^＋ regulatory T cells derived from thymus. It plays an important role in self-tolerance and allograft-tolerance through cell-contact dependent mechanism. This review described the advances of study on the probable regulatory factors of the naturally occurring regulatory T cells, such as Foxp3, IL-2, TGF-β1, dendritic cells and CTLA-4. As a marker of Treg, the expression of Foxp3 could be used to identify regulatory T cells. The combination of interferon 2 and IL-2Rα would activate Treg and promote its proliferation through the phosphorylation of STATS . TGF-β1 on the cell surface may influence the function of Treg, while the secretion type of TGF-β may promote the proliferation of Treg, Dendritic cells can positively or negtively regulate Treg, which depends on the signal transduction pathway. CTLA-4 expressed on the surface of Treg might bind to the B7 molecule on the DC, effective cell or Treg itself directly or indirectly regulate Treg.
出处
《中国实验血液学杂志》
CAS
CSCD
2008年第1期207-212,共6页
Journal of Experimental Hematology
作者简介
通讯作者：谢彦晖，教授．电话：（021）62489999—6102．E-mail：yahhuixie@163．com
