摘要
目的:研究我院ADR发生特点,规避临床用药风险,掌握监测工作现状。方法:以Excel电子表格形式下载2004年～2006年ADR报告表,对有关数据进行适当转换后,进行统计分析。结果:1933例ADR报告中抗感染药物所占比例最大,其次为抗肿瘤药和中药;ADR累及器官(系统)主要为全身性损害、消化系统;1601例(82.8%)ADR由静脉给药途径所致;新的、严重的报告共涉及10类68个药品,报告填写质量呈逐年上升趋势。结论:ADR发生与药物使用频率密切相关,且与多因素关联;应重视对新的、严重ADR报告的分析,及时筛选信号、展开调研、发布预警,形成有效信息流,降低临床用药风险。
Objective：To investigate the essential features of adverse drug reaction （ADR） which take place in our hospital, avoid risk of clinical drug use, and control the present situation of ADR monitoring.Methods：ADR reports in 2004-2006 were down-loaded from provincial center for ADR monitoring interms of Excel form.Some dataformats were coverted or added necessarily.All items of the report form were collected and analyzed.Results：The anti-infective agents, antineoplastic agents and TCM ranked first, second and third among 1933 ADR reports.The lesions of ADR involved body as a whole-general disorders, then gastrointestinal system.1601 （82.8%） ADR reports were included by the intravenous route of administration.10 categories drugs and total 68 kinds of medicines were involved in 116 new and severe ADR reports.Conclusion：The multiple factors lead to the high frequency of ADR cases, especially drug use frequency.h is essential to analyze the new and severe ADR reports, extract signal, expand safe research, announce pharmacovigilance, reduce to a lower rank of drug use.
出处
《中国药物应用与监测》
CAS
2008年第1期7-11,共5页
Chinese Journal of Drug Application and Monitoring
关键词
药品不良反应
质量评估
信号
预警
Adverse drug reaction
Quality assessment
Signal
Pharmacovigilance
作者简介
陈超，女，药师，研究方向：临床药学。Tel：（010）66937146，E-mail：plaadr301@126．com
