摘要
AIM: To examine the ultrastructural changes after ursodeoxycholic acid (UDCA) treatment in hepatocytes from experimentally induced fibrotic livers.METHODS: Liver fibrosis was induced in male Sprague-Dawley rats with CCl4 for 12 wk, and the rats were divided into two groups. Group I was treated with saline and group Ⅱ with UDCA (25 mg/kg per day) for 4 wk. All the rats were killed at wk 16. Mitochondria, nuclei, rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) of hepatocytes were evaluated according to a scoring system.RESULTS: Mitochondria, nuclei, RER and SER injury scores in group Ⅱ were significantly lower than those in groupⅠ(P < 0.001). CONCLUSION: UDCA alleviates hepatocyte organelle injury in CCl4-induced liver fibrosis.
AIM： To examine the ultrastructural changes after ursodeoxycholic acid （UDCA） treatment in hepatocytes from experimentally induced fibrotic livers.METHODS： Liver fibrosis was induced in male Sprague-Dawley rats with CCl4 for 12 wk, and the rats were divided into two groups. Group I was treated with saline and group Ⅱ with UDCA （25 mg/kg per day） for 4 wk. All the rats were killed at wk 16. Mitochondria, nuclei, rough endoplasmic reticulum （RER） and smooth endoplasmic reticulum （SER） of hepatocytes were evaluated according to a scoring system.RESULTS： Mitochondria, nuclei, RER and SER injury scores in group Ⅱ were significantly lower than those in groupⅠ（P 〈 0.001）. CONCLUSION： UDCA alleviates hepatocyte organelle injury in CCl4-induced liver fibrosis.
作者简介
Correspondence to： Mehmet Refik Mas, Associate Professor, Department of Internal Medicine, Gulhane School of Medicine, GATA Ic Hastaliklari Bilim Dali, Etlik 06018, Ankara, Turkey. refikmas@yahoo.com Telephone： ＋90-312-3044016 Fax： ＋90-312-3044000
