摘要
目的：研究饮酒对乙型肝炎病毒（HBV）感染之病程经过的影响。方法：1392例男性成年HBV感染者依饮酒与否分为两组，各以复查时或死亡诊断为转归诊断并同初诊诊断作对比分析。结果：两组的病情发展（持续携带→慢性肝炎→肝硬化→肝细胞癌）比例均具统计学显著性差异。饮酒组的脂肪肝B超显像和血清抗－HCV阳性率亦明显高于不饮酒组。结论：本文研究分析认为，饮酒对于HBV感染的病变过程确有促进影响。
Objective: To study the effect of alcohol-intake on the course of HBV infection.Methods: 1392 male individuals, aged>18 suffering from HBV infection, were allocated into two groups according to the comsumption of≥100g/d×5yrs or more of Chinese spirits. The mean observation period was 10.30±5.03yrs. Results :Among the drinking group, 65.7% of asymptomatic carrier (ASC) remained in the same status, 13.0% progressed to chronic hepatitis (CH), 19.4% to liver cirrhosis (LC) and 1.9% died of hepatocellular carcinoma (HCC), while in non-drinking group,they were 83.1%, 10.0%, 6.7% and 0.2% respectively, 61.2% of CH of drinking group remained unchanged, 29.6% advanced to LC and 9.2% died of HCC, whereas in non-drinking group, they were 78.6%, 17.2% and 3.5% respectively. 74.7% of LC remained as before, and 25.3% developed cancer in drinking group, but in non-drinking group, they were 86.5% and 13.5% respectively. The incidence of fatty liver and positive serum anti-HCV in drinking group were a1so higher than those in non-drinking group. Conclusionsf It is concluded that drinking can influence the course of HBV infection. The rates of development of CH, LC and HCC between the two groups show significant statistical difference, in particular, the incidence of cancer being very significant.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1997年第1期7-9,共3页
Chinese Journal of Digestion
关键词
饮酒
病程
乙型肝炎
病毒感染
肝硬化
流行病学
Alcohol intake Hepatitis B virus infection Liver cirrhosis Hepatocellular carcinoma
