摘要
用HPLC和UV方法研究了腺苷钻胺在不同物理状态和不同pH溶剂中受不同光强度照射后的光解情况,结果表明在相同光强下本品固体状态较液体状态稳定得多,在酸性缓冲液中(pH2.0)降解较中性缓冲液(pH7.0)、水(pH5.5)慢、在相同物理状态下光强度越大则光解速度越快,提示本品原料应避光保存,而溶液由于降解较快,应避光操作并尽快测定。
The paper studied the photolysis of cobamamide under different light intensites. The result showed that the solid state of Cobamamide was more stable than the liquid state, and the photolysis of cobamamide in acid buffer(pH2. 0) was slower than that in neutral buffer and water (pH 5. 5) under the same light intensity. In the same physical state, the more light intensity, the more photolysis speed. The test indicated that the solid state must be protected from light, and the solution must be measured as quickly as possible under the conditions protected from light.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1997年第3期183-186,共4页
Journal of China Pharmaceutical University
