摘要
目的探讨核因子-кBp65(NF-кBp65)和乙酰肝素酶(HPA)在大肠癌浸润、转移中的作用及其相关性。方法应用免疫组织化学SP法检测60例大肠癌、23例大肠管状腺瘤及26例正常肠黏膜组织中NF-кBp65和HPA的表达情况。结果大肠癌、大肠管状腺瘤和正常肠黏膜组织中NF-кBp65和HPA的阳性率间差别有统计学意义(P<0.01),且大肠癌、大肠管状腺瘤与正常肠黏膜NF-кBp65和HPA阳性率间两两比较差别均有统计学意义(P<0.017);不同浸润深度组,大肠癌组织NF-кBp65和HPA的阳性率间差别有统计学意义(P<0.017);淋巴结转移组和无淋巴结转移组癌组织NF-кBp65和HPA阳性率间差别有统计学意义(P<0.05)。NF-кBp65和HPA在大肠癌中的表达呈正相关(r=0.49,P<0.01)。结论NF-кBp65和HPA是大肠癌浸润、转移的重要因子,NF-кBp65可能通过上调HPA的表达来促进大肠癌的浸润、转移。
Objective To evaluate the effect and correlation of NF - κBp65 and HPA in infiltration/metastasis of colorectal carcinoma. Methods The expressions of NF -κBp65 and HPA were detected by SP immunohistochemical method in 60 cases of colorectal carcinoma, 23 cases of colorectal adenoma and 26 cases of normal colorectal mucosa, Results The difference of the positive expressions of NF -κBp65 and HPA among the colorectal carcinoma, colorectal adenoma and normal colorectal mucosa is significant （ P 〈0. 05）, and the difference between any tow groups is significant （ P 〈0. 05） ; the positive expression of NF -κBp65 and HPA were closely correlated with depth of tumor infiltration and metastasis of lymph node （ P 〈 0. 05） , and there was no correlation with the age, gender and differential degree （ P 〉 0. 05 ） ; The positive expressions of NF -κBp65 and HPA is correlated in the colorectal carcinoma （ r = 0.49, P 〈 0. 05 ）. Conclusion NF - κBp65 and HPA are important factors in infiltration and metastasis of colorectal carcinoma, NF - κBp65 may promote the infiltration and metastasis by up - regulating the expression of HPA.
出处
《中国全科医学》
CAS
CSCD
2008年第4期286-288,共3页
Chinese General Practice
关键词
核因子-ΚB
乙酰肝素酶
大肠癌
肿瘤转移
浸润
NF- kappa B
Heparanase
Intestinal neoplasms
Neplasm metastasis
Infiltration
作者简介
通讯作者：郑淑芳，266033山东省青岛市，青岛大学医学院附属海慈医院病理科，硕士研究生导师；E-mail：zhengshf@126．com
