摘要
目的研究加味小柴胡汤对醋氨酚所致肝损伤的保护作用。方法以醋氨酚致肝损伤动物为模型,观察小鼠脂质过氧化物(LPO)、谷胱甘肽(GSH)、白介素-2(IL-2)、白介素-6(IL-6)及肝组织的病理学检查,探讨加味小柴胡汤保护肝损伤的作用和机理。结果加味小柴胡汤能降低小鼠LPO,IL-6,升高GSH,IL-2水平,改善肝组织病变。结论加味小柴胡汤对醋氨酚所致肝损伤有明显的保护作用,其机制可能与抗氧化及免疫调节有关。
Objective To study the protective effect of Modified minor Radix Bupleuri Decoction on hepatic injury induced by Paracetamol. Methods With hepatic injury animal model, we observed LPO, GSH, IL - 2, IL - 6,liver histopathology of mice to investigate the effect and mechanism of modofied minor Radix Bupleuri Decoction on hepatic injury caused by paracetamol. Results Modified Minor Radix Bupleuri Decoction could depress levels of LPO and IL - 6, and increase the levels of GSH and IL - 2, ameliorate pathological changes of hepatic tissue. Conclusion Modified Minor Radix Bupleuri Decoction has obvious protective effect on hepatic injury caused by paracetamol. Its mechanism maybe concerned with antioxidation and immunomodulation.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第1期130-131,共2页
Lishizhen Medicine and Materia Medica Research
关键词
加味小柴胡汤
醋氨酚
肝损伤
机制
Modified Minor Radix Bupleuri Decoction
Paracetamol
Hepatic injury
Mechanism
作者简介
谢斌（1975-），男（汉族），江西上饶人，现任江西中医学院基础医学院讲师，博士学位，主要从事中西医结合基础研究工作．
