摘要
目的分析60例亚临床甲状腺功能减退症(亚临床甲减)患者血脂、血糖、血尿酸水平变化及其临床意义。方法测定60例亚临床甲减患者的血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、血糖(GLU)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血尿酸(UA)水平,并据TSH浓度分为Ⅰ亚组(TSH<10.0 mIU/L)和Ⅱ亚组(TSH≥10.0 mIU/L),分别与56例健康对照组比较及行亚组间比较。结果与健康对照组比较,亚临床甲减组及2个亚组的TSH、TC、TG、LDL-C、UA水平明显升高,而HDL-C明显下降,有显著性差异(P均<0.05),尤以Ⅱ亚组的TC、TG、LDL-C、UA升高最明显(P均<0.01);2个亚组间的TC、TG、LDL-C、UA、HDL-C水平也有显著性差异(P均<0.05);而血糖水平虽有轻微下降,但均无显著性差异。结论亚临床甲减组及2个亚组的TC、TG、LDL-C、HDL-C、UA水平有明显差异,而血糖变化则无显著性差异。亚临床甲减在促进动脉粥样硬化的过程中,血脂代谢紊乱和高尿酸血症可能是重要的危险因素,而与血糖变化无关。
Objective It is to analyze the variety and the clinic signification of lipids, plasma glucose, blood uric acid in patients with subclinical hypothyroidism. Methods The levels of TSH, FT3, FT4, FPG, TC, TG, LDL - C, HDL - C and UA were measured in 60 patients with subclinical hypothyroidism. The patients were divided into two groups according to TSH level： sub-group Ⅰ （TSH〈 10.0 mIU/L） and sub-group Ⅱ （TSH≥10.0 mIU/L）, then, compared with 56 control subjects, and compared with each other. Results Compared with control subjects, patients with subclinical hypothyroidism, as well as patients with that two groups had higher TSH, TC, TG, LDL - C, UA; and lower HDL - C （ P 〈 0.05 ）. Especially, the sub-group Ⅱ had higher TC, TG, LDL- C and UA （all P 〈 0.01 ）. Both sub-group Ⅰ and sub-group Ⅱ showed a significant difference in TC, TG, LDL - C, UA, HDL - C （P 〈 0.05）, FPG were no different. Conclusion Both group of subclinical hypothyroidism and two sub-groups show a significant difference in TC, TG, LDL - C and UA, except FPG. Within subclinical hypothyroidism patients, lipid dysfunction and high uric acid may be important risk factors for the development of atherosclerotic cardiovascular disease, there is no correlation with PFG.
出处
《现代中西医结合杂志》
CAS
2008年第6期816-817,824,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
亚临床甲状腺功能减退症
血脂
血糖
血尿酸
subclinical hypothyroidism
lipids
plasma glucose
bleed uric acid
作者简介
邓顺有（1973-），女，主治医师，研究生在读，主要从事临床分泌工作及教学。
