摘要
AIM: To evaluate the predictive value of D-dimer as a predictive indicator of portal vein thrombosis (PVT) after portal hypertension surgery in hepatitis B virus-related cirrhosis. METHODS: A prospective study was carried out in 52 patients who had undergone surgery for portal hypertension in hepatitis B virus-related cirrhosis. Changes in perioperative dynamic D-dimer were observed. The sensitivity, specifi city, positive predictive values and negative predictive values of D-dimer were calculated, and ROC curves were analyzed. RESULTS: The D-dimer levels in the group developing postoperative PVT was signifi cantly higher than those in the group not developing PVT (P = 0.001), and the ROC semi-quantitative and qualitative analysis of D-dimer showed a moderate predictive value in PVT (semi- quantitative value Az = 0.794, P = 0.000; qualitative analysis: Az = 0.739, P = 0.001). CONCLUSION: Dynamic monitoring of D-dimer levels in patients with portal hypertension after surgery can help early diagnosis of PVT, as in cases where the D-dimer levels steadily increase and exceed 16 μg/mL, the possibility of PVT is very high.
AIM： To evaluate the predictive value of D-dimer as a predictive indicator of portal vein thrombosis （PVT） after portal hypertension surgery in hepatitis B virus-related cirrhosis.METHODS： A prospective study was carried out in 52 patients who had undergone surgery for portal hypertension in hepatitis B virus-related cirrhosis. Changes in perioperative dynamic D-dimer were observed. The sensitivity, specificity, positive predictive values and negative predictive values of D-dimer were calculated, and ROC curves were analyzed.RESULTS： The D-dimer levels in the group developing postoperative PVT was significantly higher than those in the group not developing PVT （P = 0.001）, and the ROC semi-quantitative and qualitative analysis of D-dimer showed a moderate predictive value in PVT （semiquantitative value Az = 0.794, P = 0.000; qualitative analysis： Az = 0.739, P = 0.001）.CONCLUSION： Dynamic monitoring of D-dimer levels in patients with portal hypertension after surgery can help early diagnosis of PVT, as in cases where the D-dimer levels steadily increase and exceed 16 μg/mL, the possibility of PVT is very high.
基金
Supported by Technology Support Fund of Guangdong Province, No. 2004B35001007
作者简介
Correspondence to： Dr. Mei-Hai Deng, Department of Hepato-biliary Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China. drdmh@medmail.com.cn Telephone： ＋86-20-85613318 Fax： ＋86-20-85262937
