摘要
目的比较二甲双胍缓释片(卜可)与速释片(格华止)对血糖、胰岛素敏感性及胰岛β细胞功能的影响。方法多中心随机对照设计。150例2型糖尿病患者经2～3周格华止导入期后随机分为格华止组和卜可组,每组75例。格华止500mg每日3次、卜可1500mg晚餐后服用,共12周。结果12周后,格华止或卜可均能显著降低糖尿病患者的BMI和HbA1c,卜可组标准餐后120min血糖显著高于格华止组(11.0±3.1mmol/Lvs7.4±2.6mmol/L,P<0.05);两组患者胰岛素曲线下面积(AUCIns)、胰岛β细胞功能指数和胰岛素抵抗指数均有降低趋势,但组间或组内无统计学差异。结论卜可的降糖效能以及对2型糖尿病患者胰岛素抵抗和胰岛素分泌功能的影响与相同剂量的格华止基本相似。
Objective To investigate the efficacy effects on pancreatic islet function and insulin resistance. of extended-release metformin （MXR） and its Methods A randomized multicenter study was conducted. After 2-3 weeks of lead-in period with Glucophage, 150 diabetics were randomized into immediate-release metformin （MIR） group and MXR group （75 subjects for each group）. The MIR group took Glucophage 500rag thrice-daily after meals, while the MXR group took 1500rag MXR once-daily after dinner for 12 weeks. Results Either MIR or MXR significantly decreased HbA1 c level and body mass index in diabetic patients after 12-week treatment. The postprandial glycemia at 120 min after a meal was higher in MXR group than in MIR group （11. 02±3.08mmol/L vs 7. 4±2. 61mmol/L, P〈0.05）. The areas un2 der curve of insulin （AUCins）, islet function index （HOMA-β） and insulin resistant index （HOMA-IR） were slightly diminished after 12 weeks of treatment in both groups, but there were no differences within or between groups. Conclusion The efficacy of MXR in lowering hyperglycemia is comparable to MIR. The effects of MXR on insulin resistance and islet function are similar to MIR.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2007年第12期711-713,共3页
Chinese Journal of Diabetes
关键词
二甲双胍缓释片
胰岛素抵抗
胰岛功能
Extended-release metformin
Insulin resistance
Islet function
作者简介
通讯作者：洪天配，E-mail：tph066@bjmu．edu．cn
