摘要
背景与目的:近年来有学者主张对结直肠癌患者行围手术期化疗,本研究旨在探讨围手术期化疗对结直肠癌预后的影响。方法:选择2001年8月至2003年8月在我院胃肠外科行根治术的167例DukesRB、C期结直肠癌患者,电脑抽取随机数方法随机分为对照组和试验组,两组均行根治性手术,试验组采用5-FU进行围手术期化疗,两组术后均采用5-FU/CF方案进行全身化疗。比较两组的不良反应、术后复发转移率和生存率。结果:两组的不良反应发生率和程度比较差异无统计学意义。全组总的术后复发转移率为42.5%,对照组为49.4%,试验组为34.6%,两组比较差异有统计学意义(P=0.038)。全组总的术后1、3、4年生存率分别为97.6%、74.7%、61.8%,对照组分别为95.3%、67.1%、54.8%,试验组分别为100%、82.7%、69.1%,两组比较差异有统计学意义(P=0.046)。结论:围手术期化疗能改善结直肠癌患者的预后。
BACKGROUND ＆ OBJECTIVE： Recently, some scholars advocate perioperative chemotherapy for colorectal cancer. This study aimed to investigate the impact of perioperative chemotherapy on the prognosis of colorectal cancer. METHODS： From Aug. 2001 to Aug. 2003, 167 patients with Dukes＇ B or C colorectal cancer were randomized into two groups： 82 in trial group received perioperative chemotherapy using 5-fluorouracil （5-FU）, while 85 in control group received no perioperative chemotherapy. All patients received adjuvant chemotherapy of 5-FU/leucovorin regimen. The adverse events, recurrence rate and survival rate were compared between these two groups. RESULTS： There was no difference in adverse events between the two groups. The overall recurrence rate was 42.5%; it was significantly lower in trial group than in control group （34.6% vs. 49.4%, P=0.038）. The overall 1-, 3-, and 4-year survival rates were 97.6%, 74.7% and 61.8%; they were significantly higher in trial group than in control group （100% vs. 95.3%, 82.7% vs. 67.1%, and 69.1% vs. 54.8%, P=0.046）. CONCLUSION： Perioperative chemotherapy can improve the prognosis of colorectal cancer.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2007年第12期1350-1353,共4页
Chinese Journal of Cancer
关键词
结直肠肿瘤
围手术期
化学疗法
预后
Colorectal neoplasm
Perioperative period
Chemotherapy
Prognosis
作者简介
通讯作者：龚志军,Tel：86—750—3165725,E—mail：gongzhij@21cn．com
