摘要
目的研究卵巢腺癌、浆液性或黏液性囊腺瘤及正常卵巢组织肿瘤相关巨噬细胞(TAM)和肥大细胞(MC)计数及其临床病理意义。方法43例卵巢腺癌、15例浆液性囊腺瘤、15例黏液性囊腺瘤和10例正常组织标本常规制作石蜡包埋切片,TAM和MC染色方法为EnVisionTM免疫组化法。结果卵巢腺癌TAM和MC计数明显高于浆液性或黏液性囊腺瘤及正常组织(P<0.01);浆液性或黏液性囊腺瘤TAM、MC计数明显高于正常组织(P<0.01);组织学分级G1、临床分期Ⅰ+Ⅱ,无淋巴结转移和未侵犯周围组织器官的腺癌病例TAM、MC计数明显低于组织学分级G3、临床分期Ⅲ+Ⅳ、淋巴结转移和侵犯周围组织器官病例(P<0.05),卵巢腺癌TAM计数和MC计数呈密切正相关(r=0.42,P<0.01)。结论TAM和MC计数可能是反映卵巢腺癌发生、进展、生物学行为及预后的重要标志物。
Objective To study on the counts of TAM and MC and their clinicopathological significances in ovarian adenocarcioma, serous or mucinous cystoadenoma and normal tissues. Methods EnVisiomTM immunohistochemistry was used for the counts of TAM and MC in the routinely paraffin - embedded sections from the specimens of ovarian adenocarcinoma （ n = 43 ） , serous cystoadenoma （ n = 15） , mucinous cystoadenoma（n = 15） , and nomal tissues（n = 10）. Results The counts of TAM and MC were significantly higher in adenocarcinoma than those in serous cystoadenoma, mucinous cystoadenoma or normal tissues （P 〈 0.01 ）. The counts of TAM and MC were significantly higher in serous or mucinous cystoadenoma than ＂that in normal tissues （P 〈 0.01 ）. The counts of TAM and MC in the cases of histologic grade G1, clinical stage Ⅰ ＋ Ⅱ, no - metastasis of regional lymphnode and no - infiltration of peritumoral tissues were significantly lower than those in the ones histologic grade G3 , clinical stage Ⅲ ＋ Ⅳ, metastasis of reginal lymphnode and infiltration of peritumoral tissues in ovarian adenocarcinoma （P 〈 0.01 ）. The closely positive correlation was found between the counts of TAM and MC in ovarian adenocaricnoma （r =0.42,P 〈 0.01 ）. Conclusions The counts of TAM and/or MC might be important biological markers for reflecting the carcinogenesis, progression, biological behaviors and progniosis of ovarian adenocarcinoma.
出处
《医学研究杂志》
2007年第12期26-28,F0003,共4页
Journal of Medical Research
基金
深圳市科技计划局资助研究项目(编号2005-227-96)
