摘要
乳化交联法是制备壳聚糖微球常用的工艺，但在制备过程中，常出现微球产物粘连的现象。分析了搅拌速度、油水体积比、表面活性剂添加量和交联剂用量等影响微球粘连的因素，优化出了分散性好，粒度均匀的壳聚糖微球制备工艺参数。结果表明，搅拌速度〉350r／min，油水体积比〉2．5，表面活性剂span80用量为水相的20％时，可获得分散性好的壳聚糖微球，微球的粒径可以控制在1～5μm之间。
Emulsion-crosslink technique is commonly used to prepare chitosan microspheres, however, adhesion may appear among microspheres if technological parameters can not be controlled properly. Experiments indicated that stirring speed, volume ratio of oil and water, volume of surface active agent and cross linker influence the dispersing of the product. Chitosan microspheres with good dispersing were obtained through using the following parameters： a stirring speed of more than 350 rpm, a volume ratio of oil and water of more than 3.5, the masses of surface active agent to be used set to be 20% of water phase. Diameters of Chitosan microspheres could be in the range of 1-5μm.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2007年第A05期1923-1925,共3页
Journal of Functional Materials
基金
国家重点基础研究发展计划（973计划）资助项目（2005CB623905） 致谢：感谢北京市教育委员会共建项目建设计划基金的资助.
关键词
乳化交联
壳聚糖
微球
粘连
emulsion-crosslink
chitosan
microspheres
adhesion
作者简介
王怀玉，在读硕士研究生。
通讯作者：董利民
