摘要
肿瘤细胞的生理生化特性不同于正常的组织细胞,其中某些基因会出现异常表达。基因表达上调为靶向给药提供了靶点,从而避免在治疗肿瘤时伤及正常细胞。脂肪酸合成酶(fatty acid synthase,FAS)和人表皮生长因子受体2(human epi-dermal growth factor receptor-2,HER2)都是在肿瘤细胞中高表达的分子。针对HER2的赫赛汀(herceptin)已应用于乳腺癌的临床治疗并取得了良好疗效,而针对FAS的药物浅蓝霉素也正在进行临床试验。近年来研究发现,FAS和HER2在某些肿瘤细胞(如乳腺癌细胞、卵巢癌细胞等)中同时高表达,相互之间存在着信号通路上的联系,而且用药后具有协同抑制作用。本文对肿瘤细胞中二者的相互联系作一综述。
Tumor cells have different physiological and biochemical features as compared to normal cells; abnormal expressi of certain genes is also found in tumor cells. Over-expression of genes provide targets for targeted-administration of drugs, which can avoid damage to normal cells during treatment of tumors. Fatty acid synthase （FAS） and human epidermal growth factor receptor-2 （HER2） are both over-expressed in some tumor cells. Herceptin, an HER2-targeted agent, has been used to treat HER2-positive breast cancer patients worldwide and has obtained satisfactory outcome. Cerulomycin, an agent-targeting FAS, is now in FDA clinical trial. Recent researches have shown that FAS and HER2 are simultaneously over-expressed in some tumors, such as breast cancer cells and ovarian cancer cells; and there is a connection between their signal pathways and a synergistic effect between them. This paper reviews the relationship between FAS and HER2 in tumor cells.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2007年第11期1255-1258,共4页
Academic Journal of Second Military Medical University
基金
国家重点基础研究发展计划("973"计划)(2002CB523100).~~
关键词
肿瘤
脂肪酸合成酶
受体
表皮生长因子
信号转导
基因表达
neoplasms
fatty acid synthase
receptor,epidermal growth factor
signal transduction
gene expression
作者简介
张妤，硕士生．E—mail：OCT0072004@yahoo．com．cn
Corresponding author. E-mail ： yinzfk@yahoo.com.cn
