TGFβ1基因变异与疾病相关性研究展望被引量：13

Progress of research on the correlation between transforming growth factor β1 gene mutation and disease

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摘要转化生长因子β1(TGFβ1)自1972年发现以来,相关研究取得了长足进展,其基因染色体定位、基因结构、表达、蛋白结构、受体结合、信号传导、生物学效应等均基本明确.本文介绍了TGFβ1的结构和功能,特别是他在肝纤维化中的独特作用的同时,重点讨论TGFβ1基因单核苷酸多态性(SNP)对其功能的影响及其在疾病中的意义及前景,以进一步了解该多肽类生长因子在以肝病为代表的多种疾病中的病理意义及潜在的诊断、干预治疗前景. Since the description of transforming growth factor （TGF） β1 became known in 1972, much progress has been achieved in its genetic location, gene structure and expression, protein structure, receptor binding, and signal transduction, as well as its biological effects. Here we introduce the structure and function of TGFβ1, with an emphasis on its special effects on liver fibrosis. Single nucleotide polymorphisms of the TGFβ1 gene and its effects on disease development and prediction are also discussed to reveal the pathogenesis of this polypeptide growth factor and its potential in disease diagnosis and intervention.

作者高春芳

机构地区中国人民解放军第二军医大学附属东方肝胆外科医院实验诊断科

出处《世界华人消化杂志》 CAS 北大核心 2007年第28期2959-2965,共7页 World Chinese Journal of Digestology

基金国家自然科学基金资助 No.30270605 No.30571774~~

关键词转化生长因子Β1 进展疾病 Transforming growth factor β1 Progress Disease

分类号 R362 [医药卫生—病理学]

作者简介高春芳,1993年第二军医大学博士．研究员，主要从事临床实验诊断学研究，专长于肝病的基础和临床实验诊断研究．通讯作者：高春芳，200438，上海市长海路225号，中国人民解放军第二军医大学附属东方肝胆外科医院实验诊断科，gaocf1115@yahoo．com 电话：021-25070850 传真：021-25070850

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参考文献52

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