摘要
在成功制备[(99m)~Tc＜N]2+核的基础上，通过配体交换反应制得放化纯大于95％的(99m)~TcN-TBI.(99m)~TcN-TBI在制备后室温放置9h放化纯不变，分配系数P=50.52小鼠实验结果显示：(99m)~TcN-TBI，(99m)~TcN-TBI和加吐温-80的(99m)~TcN-TBI（T）有明显不同的生物分布．特别是(99m)~TcN-TBI（T）的早期肝摄取低，在静注后5min心肝比为1．15，且心肌摄取高，清除快，有较高的心血和心肺比．
On the base of successfully obtained [99mTc<N] core, the complex 99mTcN-TBI was prepared through ligand - exchange reaction. The RCP of 99mTcN-TBI was over 95% by TLC. The study of stability and partition coefficient of 99mTc-TBI showed that the complex was high lipophilic and stable over 9h in room temperature. The biodistribution of 99mTc-TBI in mice was different from that of 99mTc-TBI. Especially, the complex with Tween- 80 (represent as 99mTc-TBI) show high myocardium uptake and with rapid washout, and has low liver uptake, low blood uptake and washout from lung rapidly. Based on these results, 99mTc- TBI(T) exhibits the most promising properties for further studies.
出处
《北京师范大学学报（自然科学版）》
CAS
CSCD
北大核心
1997年第2期239-242,共4页
Journal of Beijing Normal University(Natural Science)
关键词
心肌显像剂
特丁基异腈
放射性药物
显像质量
myocardial imaging agent
99mTcN-TBI
Tween - 80
99TcN- TBI(T)
mouse,biodistribution
