摘要
目的观察麻红止哮合剂对与哮喘气道重塑密切相关的血管内皮生长因子(VEGF)与碱性成纤维细胞生长因子(b-FGF)的影响,探讨其治疗哮喘慢性持续期的作用途径。方法SD大鼠40只,随机分为正常组、造模组、激素组和中药组。以腹腔注射100g/L卵蛋白(OVA)1mL和10g/L的OVA吸入激发制成支气管哮喘模型。激素组和中药组在每次雾化前20min给予强的松或中药干预。空白组和造模组在每次雾化前20min给予2mL生理盐水。用ELISA法测定血清VEGF与b-FGF浓度。结果造模组血清VEGF与b-FGF浓度较正常组、激素组和中药组明显增加(P<0.05)。正常组、激素组和中药组组间比较,血清VEGF浓度有显著差异(P<0.05);正常组、激素组和中药组组间比较,血清b-FGF浓度无显著性差异(P>0.05)。结论麻红止哮合剂治疗哮喘慢性持续期的作用途径,可能有一部分是通过降低血清VEGF、b-FGF浓度来延缓支气管哮喘气道重塑的形成,具有和强的松相似的效果。
Objective To investigate the effect of Mahong decoction on serum VEGF and b-FGF of rat model bronchus asthma airway rcmolding. Method Forty SD rats randomly divided into four groups： blank group, asthma group, hormone group, Chinese medicine group. The asthmatic model was established by sensitization and challenge with ovalbumin, and the rats in the hormone group and Chinese medicine group conferred hormone and Chinese medicine before the challenge. ELISA was used to measure the level of serum VEGF and b-FGF. Results The serum VEGF and b-FGF in asthma group was higher than in other groups （P〈0.05）. The level of serum VEGF in blank group, hormone group, Chinese medicine group were different （P〈0.05）. The level of serum b-FGF in blank group, hormone group, Chinese medicine group were similar （P〉0.05）. Conclusion Mahong decoction may control the level of serum VEGF and b-FGF of rat model of bronchus asthma airway rcmolding, which has the similar result with hormone.
出处
《中国中医药信息杂志》
CAS
CSCD
2007年第10期32-33,共2页
Chinese Journal of Information on Traditional Chinese Medicine
基金
首都医学发展科研基金资助(2005-8F-Ⅱ-029)
