摘要
将药物——消炎痛和聚乳酸(PLA)同时溶解在三氯甲烷∶丙酮(体积比2∶1)的混合溶液中,制得均匀的纺丝液,通过静电纺丝制备载药PLA纤维膜。通过扫描电镜(SEM)观察其形貌结构;通过紫外分光光度计检测其释放在磷酸缓冲溶液(PBS)中药物的吸光度,并计算其释药速率。结果表明:纤维的平均直径随着含药量的增加而减小,随着PLA质量分数的增加而增加;释药速率随着纤维直径的减小而加快;与纯药粉的释药速率相比,载药PLA纤维膜有明显的缓释性,提高了药物的利用率及安全性。
Polylactide（PLA） and indomethacin were dissolved in a mixxed solvent of chloroform and acetone （2/1 v/v） to make even spinning solution. Then drug carrier PLA microfibers were prepared by electrospining. The microfibers morphology was observed by SEM. The absorbency of the drug in PBS was detected and the velocity of drug release was counted by UV-visible spectroscopy. The results showed the average diameter of microfibers was decreased when the concentration of drug increased, and the diameter was in- creased with the concentration of PLA increased. The velocity of drug release was increased when the diameter of the fiber reduced. Compared with drugs, PLA microfibers had obviously smooth release of drug and improved therapeutic efficacy and safety of drugs.
出处
《合成纤维》
CAS
北大核心
2007年第9期19-21,25,共4页
Synthetic Fiber in China
基金
江苏省高校重点实验室开放研究课题(编号S8115033)
关键词
PLA
消炎痛
静电纺比
药物释放
PLA, indomethacin, electrospinning, drug release
作者简介
何莉（1982-）．女．硕士研究生．主要研究方向为纳米纤维及其功能性。
