NT-proBNP评价急性ST段抬高型心肌梗死早期经皮冠状动脉介入术后心功能改善的临床价值被引量：1

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摘要目的探讨早期经皮冠状动脉介入术对氨基末端脑利钠肽前体(amino-terminal-pro-brainnatri-ureticpeptide,NT-proBNP)的血浆水平是否存在调节作用,以及血浆NT-proBNP水平是否可以预测左室功能的长期预后。方法40例急性ST段抬高型心肌梗死后患者,其NT-proBNP水平分别于入院时、入院4,24,48h,14d后测定,其中28例患者的梗死相关血管于6h内开通(6h开通组),12例患者的梗死相关血管于6h后开通(6h闭塞组)。超声心动图测定入院时及入院14d的左室舒张末期容积指数(LVEDVI)、左室收缩末期容积指数(LVESVI)及左室射血分数(LVEF)。结果在6h开通组,NT-proBNP水平在入院后缓慢上升,并于第24小时达到高峰值;而在6h闭塞组其NT-proBNP水平更高,相对于6h开通组,在4,24,48h其水平明显增高具有统计学意义。6h开通组其心室容积指数较6h闭塞组一致性下降,LVEF的增加具有统计学意义。结论血浆NT-proBNP水平可以预测急性心肌梗死后左室功能改善,早期经皮冠状动脉介入术与NT-proBNP的动态变化明显相关。

作者肖长华杨希立许兆延张健愉陆琼芳

机构地区广东省佛山市第一人民医院心血管内科

出处《广东医学》 CAS CSCD 北大核心 2007年第10期1669-1671,共3页 Guangdong Medical Journal

关键词氨基末端脑利钠肽前体心肌梗塞冠状动脉介入左室射血分数

分类号 R542.22 [医药卫生—心血管疾病]

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