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家族性高胆固醇血症患者新的致病基因——PCSK9基因突变分析 被引量:11

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出处 《中国动脉硬化杂志》 CAS CSCD 2007年第7期518-518,共1页 Chinese Journal of Arteriosclerosis
基金 国家自然科学基金(30470722) 北京市自然科学基金(7042021 7052010) 北京市科技新星计划项目(2004B27 2005A29)联合资助
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  • 1Lynn Htet Aung,YIN Rui-xing,MIAO Lin,HU Xi-jiang, YAN Ting-ting,CAO Xiao-li,WU Dong-feng,LI Qing,PAN Shang-ling,WU Jin-zhen (Department of Cardiology,Institute of Cardiovascular Diseases, The First Affiliated Hospital,Guangxi Medical University, Nanning 530021,China).The proprotein convertase subtilisin/kexin type 9 geneE670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations[J].岭南心血管病杂志,2011,17(S1):162-162. 被引量:9
  • 2刘舒,蔺洁,王绿娅.家族性高胆固醇血症新致病基因——枯草溶菌素转化酶9的研究进展[J].中国动脉硬化杂志,2006,14(3):260-262. 被引量:2
  • 3中国成人血脂异常防治指南[J].中华心血管病杂志,2007,35(5):390-419. 被引量:5249
  • 4刘鸿雁,张冬梅,杨永建,何津春.盐酸小檗碱对大鼠糖脂代谢的影响[J].兰州大学学报(医学版),2007,33(2):5-9. 被引量:6
  • 5Benjannet S,Rhainds D,Essalmani R,et al.NARC-1/PCSK9 and its natural mutants:zymogen cleavage and effects on the low density lipoprotein(LDL) receptor and LDL cholesterol[J].Biol Chem,2004,279 (47):48865-48875.
  • 6Cunningham D,Danley DE,Geoghegan KF,et al.Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia[J].Nat Struct Mol Biol,2007,14(5):413-419.
  • 7Hampton EN,Knuth MW.The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain[J].Proc Natl Acad Sci USA,2007,104(37):14604-14609.
  • 8Cameron J,Holla OL,Ranheim T,et al.Effect of mutations in the PCSK9 gene on the cell surface LDL receptors[J].Hum Mol Genet,2006,15 (9):1551-1558.
  • 9Poirier S,Mayer G,Benjannet S,et al.The proprotein convertase PCSK9 induces the degradation of LDLR and its closest family embers VLDLR and APOEB2[J].J Biol Chem,2008,283 (14):2363-2372.
  • 10Bedi M,Niesen D.Inhibition of squalene synthase upregulates PCSK9 expression in rat liver[J].Arch Biochem Biophys,2008,470(2):116-119.

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