摘要
目的:对本院2006年1～12月份临床分离致病菌的分布及其耐药性进行统计分析,为临床治疗提供依据。方法:采用法国VITEK-TWO全自动微生物分析仪,对1619株分离出的致病菌进行抗生素敏感性测定。结果:本院流行菌株主要以G-杆菌为主,其中肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌排列前三位;G+球菌中金黄色葡萄球菌、表皮葡萄球菌和溶血葡萄球菌排列前三位。常见的革兰阴性杆菌对美罗培南、亚胺培南、丁胺卡那等抗菌药物敏感;革兰阳性球菌对万古霉素敏感率最高。结论:我院感染致病菌以G-杆菌为主,且对抗生素的敏感性普遍下降,同时真菌的分离率也较以往有所增加,临床医生在使用抗生素时应在参考药敏试验的同时注意按梯次用药。
Objective： To investigate the distribution and drug resistance of pathogenic bacteria isolated from the clinical specimen, and provide useful information for the clinical treatment. Methods： The determination of antibiotic sensitivity of the pathogenic bacteria isolated was conducted with VITEK-TWO all-automatic microbiology analysis system. Results： The Gram-negative bacilli were the major pathogenic bacteria. Among them, Klebsiella pneumonia, Pseudomonas aeruginosa and Acinetobacter baumann were on the top three position; as same as the staphylococcus aureus, staphylococcus epidermidis and staphylococcus haemolyticus among the Gram-positive cooci. Almost all of Gram-negative bacillic were sensitive to meraopenem, imipenem, amikacin etc; Gram-positive cooci were especially sensitive to vancomycin. Conclusion： In our hospital, Gram-negative bacilli are the major pathogenic bacteria. Many of these organisms are resistant to different antibiotics. And the fungal isolating rate is increasing than before .Hence it is necessary for clinician to refer the drug sensitivity of bacteria so as to select antibiotics correctly.
出处
《天津医科大学学报》
2007年第3期349-351,355,共4页
Journal of Tianjin Medical University
关键词
耐药性
药物敏感性试验
抗菌药物
超广谱Β-内酰胺酶
致病菌
Drug resistance
Antibiotic susceptibility test
Antimicrobial agent
Extended-spectrum β-lactamase
Pathogenic bacteria
作者简介
张平（1970-）,女,副主任药师,硕士在读,研究方向：临床药学;
贺靖冬（1968-）,女,副主任技师,研究方向：细菌耐药.
