期刊文献+

低分子肝素治疗不稳定性心绞痛132例临床观察 被引量:2

在线阅读 下载PDF
导出
摘要 目的观察低分子肝素加阿司匹林治疗不稳定性心绞痛的疗效。方法将132例不稳定性心绞痛的患者随机分为治疗组(66例)和对照组(66例),均常规口服阿司匹林,治疗组加用低分子肝素,连续用7d,观察治疗前后患者心绞痛发作、心电图或动态心电图所示心肌缺血改善情况、血小板计数、凝血酶原时间和部分凝血活酶时间的变化。结果治疗组用低分子肝素加阿司匹林治疗后,心绞痛发作频率减少,心电图ST段下移恢复明显,动态心电图心肌缺血总时间缩短,与对照组相比,差异有统计学意义(P<0.01),但血小板计数、凝血酶原时间、部分凝血活酶时间与对照组相比,差异无统计学意义(P>0.05)。结论低分子肝素加阿司匹治疗比单用阿司匹林对不稳定性心绞痛治疗更有效,无明显副作用,可用于不稳定性心绞痛的常规治疗。
作者 张彦峰
出处 《内科》 2007年第5期772-773,共2页 Internal Medicine
  • 相关文献

参考文献4

  • 1胡大一,孙艺红.正确认识阿司匹林“抵抗”[J].中华心血管病杂志,2006,34(12):1057-1058. 被引量:10
  • 2Fareed P;walenga J;Kaman A.A modified stasis thrombosis model to study,the antithromtobic actions of heparin and its fractions,1995.
  • 3Kirkeboen KA.Unstable angina pectoris pathogenesis treatment and prognosis,1995(27).
  • 4徐友德.缺血性心脏病的命名及诊断标准,1981(01).

二级参考文献9

  • 1ISIS-2 (Second International Study of Infarct Survival) Collaborative Group.Randomised trial of intravenous streptokinase,oral aspirin,both,or neither among 17 187 cases of suspected acute myocardial infarction:ISIS-2.Lancet,1988,332:349-360.
  • 2Eikelboom JW,Hirsh J,Weitz JI,et al.Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction,stroke,or cardiovascular death in patients at high risk for cardiovascular events.Circulation,2002,105:1650-1655.
  • 3Zimmerman C,Kienzle P,Weber AA,et al.Aspirin resistance after coronary artery bypass grafting.J Thorac Cardiovasc Surg,2001,121:982-984.
  • 4Zimmermann N,Wenk A,Kim U,et al.Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery.Circulation,2003,108:542-547.
  • 5Bhatt DL.Aspirin resistance:more than just a laboratory curiosity.J Am Coll Cardiol,2004,43:1127-1129.
  • 6Patrono C.Aspirin resistance:definition,mechanisms and clinical read-outs.J Thromb Haemos,2003,1:1710-1713.
  • 7Michelson AD.Platelet function testing in cardiovascular diseases.Circulation,2004,110:e489-493.
  • 8Wang TH,Bhatt DL,Topol EJ.Aspirin and clopidogrel resistance:an emerging clinical entity.Eur Heart J,2006,27:647-654.
  • 9Patti G,Colonna G,Pasceri V,et al.Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention.Results from the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) Study.Circulation,2005,111:2099-2106.

共引文献10

同被引文献7

引证文献2

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部