摘要
目的制备N-琥珀酰壳聚糖纳米粒并对其进行体外评价。方法采用乳化溶剂挥发法制备N-琥珀酰壳聚糖纳米粒;以包封率、载药量及粒径为指标,采用正交设计法对处方进行优化;考察其理化特征及体外释药行为。结果纳米粒包封率及载药量分别为62.36%和18.98%,平均粒径及zeta电位分别为(206.6±64.7)nm和(-27.2±0.2)mV;1 h药物释放达到45%,随后药物的释药行为是一个缓释过程。结论作者采用乳化溶剂挥发法成功制得N-琥珀酰壳聚糖纳米粒。该方法制得纳米粒包封率较高,制备工艺简单。
Objective To oreoare 5-fluorouracil loaded N-Succinyl-chitosan nanoparticles （5-FU-Suc-Chi/NPs） and investigate their properties in vitro. Methods 5-FU-Suc-Chi/NPs were prepared by an emulsification solvent diffusion method, With the entrapment efficiencies as references, the formulation was optimized by orthogonal design, Results The 5-FU entrapment efficiency of the nanoparticles and their loading capacity were 62.36 % and 18,98 % respectively. The Suc-Chi nanoparticles have a particle diameter （Z-av-erage） of （206.6±64.7） nm and a negative zeta potential of （ - 27.2±0.2） mV. A burst release was found in the initial 1 hour followed by a continuous sustained release in vitro for 5-FU-Suc-Chi/NPs. Conclusions The entrapment efficiency of the nanoparticles is high and the preparation method is simple.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2007年第9期521-523,581,共4页
Journal of Shenyang Pharmaceutical University
关键词
N-琥珀酰壳聚糖
纳米粒
理化特征
体外释放
N-succinyl-chitosan
nanoparticles
physico-chemical characterization
in vitro release
作者简介
颜承云（1972-），男（汉族），黑龙江鹤岗人，博士研究生，E-mail：yzyjack1999@163.com
陈大为（1959-），男（汉族），辽宁海城人，教授，博士，主要从事口服固体药物新剂型研究，Tel：024-23986308，E-mail：cdw2002yd@sina.com
