摘要
目的探讨Ⅲ型前列腺炎前列腺按摩液中细胞因子IFN-γ、IL-10、IL-4水平变化对临床症状的影响。方法按照美国国立卫生院(NIH)分类方法诊断Ⅲ型前列腺炎共76例。ⅢA型前列腺炎47例,ⅢB型前列腺炎29例。采用美国国立卫生研究院的慢性前列腺炎症状评分表(NIH-CPSI),评估疼痛症状评分、排尿症状评分;采用双抗体夹心酶联免疫法(ELISA)检测前列腺液(EPS)中IFN-γ、IL-10、IL-4水平,分析各细胞因子变化和症状评分的相关性。结果ⅢA、ⅢB型前列腺炎两组疼痛症状和排尿症状评分比较无显著性差异(P>0.05);IFN-γ、IL-10、IL-4均和疼痛症状评分呈正相关(P<0.05),其中IL-10起主要相关;IFN-γ、IL-10、IL-4均和排尿症状评分无相关(P>0.05)。结论Ⅲ型前列腺炎EPS中IFN-γ、IL-10、IL-4水平和疼痛症状有关,其中IL-10可能起主要作用;但IFN-γ、IL-10、IL-4和排尿症状无相关。
Objective To discuss IFN-γ, IL-10, IL-4 levels in expressed prostatic secretions(EPS) of type Ⅲ prostatitis and their influence on the symptoms. Methods 76 cases were classified, with type/group Ⅲ A (47 cases), type/group Ⅲ B (29 cases) according to NIH classification system. NIH pain symptom index and NIH urination symptom index were compared between the two groups; IFN-γ, IL-4 and IL-10 in EPS were detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results No significant difference of NIH pain symptom index and NIH urination symptom index was detected between the two groups(P 〉 0.05). IFN-γ, IL-10 and IL-4 had positive correlation with NIH pain symptom index (P〈0.05), and IL-10 played the key role. All cytokines had no correlation with NIH urination symptom index (P〉0. 05). Conclusion IFN-γ, IL-10 and IL-4 in EPS have correlations with pain symptom of type Ⅲ prostatitis, and IL-10 probably plays the key role; while IFN- γ, IL-10 and IL-4 in EPS have no correlations with urination symptom.
出处
《现代泌尿外科杂志》
CAS
2007年第5期308-310,共3页
Journal of Modern Urology
基金
温州市科委科研基金资助项目(Y2004A157)
作者简介
张磊(1972-),男(汉族),医学硕士,主治医师E-mail:julywww@163.com
通讯作者:翁志梁,主任医师,教授,硕士研究生导师.E-mail:wengzl2001@163.com