摘要
目的探讨非霍奇金淋巴瘤(NHL)发生胃肠道穿孔的病因、临床表现、诊断、治疗及预后。方法回顾性分析了1998年至2003年收治的8例NHL伴胃肠道穿孔患者。结果免疫组化结果示T细胞来源6例,B细胞来源2例。NHL伴胃肠道穿孔患者常分期晚、有B症状,IPI评分中高或高危,部分患者有腹痛、腹块及黑便。常有肝、脾、牙龈等部位的结外侵犯。胃肠道穿孔常发生在化疗后第3～6天。全组患者中位生存期(MST)7天。结论NHL尤其伴有胃肠道症状、溃疡及出血患者,在化疗前应对胃肠道穿孔可能性进行评价,必要时先行外科手术,再化疗。
Objective The study was to explore the etiology,clinical features,diagnosis,treatment and prevention of the gastrointestinal non-Hodgkin＇ s Lymphoma（NHL） with perforation. Methods Record of 8 patients in our hospital from 1998 to 2003,1.6% of all NHL cases in the same period,were retrospectively analyzed. Results Immunophenotyping revealed that 6 cases were T cell original and 2 cases were B cell original. All patients were presented with advanced stage, B symptom, high or high-intermediate IPI score. Some of them were presented with fever, abdominal pain, abdominal mass, gastrointestinal haemorrhage. The median survival time in patient with perforation was 7 days. Conclusion The possibility of perforation should be evaluated before chemotherapy. Surgical resection is recommended in NHL with large ulceration and gastrointestinal haemorrhage.
出处
《实用癌症杂志》
2007年第5期503-505,共3页
The Practical Journal of Cancer
关键词
非霍奇金淋巴瘤
胃肠道穿孔
诊断
治疗
Non-hodgkin＇ s lymphoma（NHL）
Gastrointestinal perforation
Diagnosis
Therapy
