摘要
２，４－二异氰酸甲苯酯致敏豚鼠符合鼻变态反应，出现典型的鼻痒、喷嚏、流涕症状［积分值（６±０．９４）分］。实验表明：克鼻敏可减少鼻局部症状的积分值（Ｐ＜０．００１），并优于立复汀对照组。结果还显示克鼻敏对致敏豚鼠鼻粘膜肥大细胞释放组织胺介质的高含量有明显的抑制作用（Ｐ＜０．００５），同时亦降低血中含量，说明其作用是通过降低变应原对肥大细胞的刺激，减少组胺释放，从而有效地控制变应性鼻炎发生的。
The allergic rhinitis model of guinea pig had been developed by intranasal application of 2,4 toluenediisocynate(TDI).The model animals showed typical allergic symptoms of rhinocnesmus,sneezing and rhinorrhea (accumulative score 6±0.94).After using Kebinmin Spray,the accumulative scores of the local nasal symptoms significantly decreased (P<0.01),which had a direct relationship with the decreasing histamine contents of nasal mucosa and blood.It is indicated that Kebinmin spray can inhibit the release of histamine from mastocyte in the nasal mucosa of the allergic animals and also reduce the histamine content of blood.The effect of Kebimin was to reduce the stimulation of allergen toward mastocyte,decrease the releasing histamine and the permeability of cappillary,reduce the leakage of fluid and macromolecular substances,increase the threshold of rhinocnesmus,so that the occurrence of allergic rhinitis is controlled.
出处
《广州中医药大学学报》
CAS
1997年第2期112-115,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
中国人民解放军总后勤部医学科研课题
关键词
变应性鼻炎
中医药疗法
克鼻敏
鼻粘膜
RHINITIS,ALLERGIC,PERENNIAL/TCM ther. @KEBIMIN/ther. use NASAL MUCOSA/drug eff. HISTAMINE/blood DISEASE MODELS,ANIMAL GUINEA PIGS
