摘要
目的观察抑毒调平液对2型糖尿病合并慢性乙肝患者T辅助(Th)细胞因子的影响。方法50例2型糖尿病合并慢性乙型肝炎(中度)患者按随机双盲原则分为治疗组、对照组(每组25例)。两组分别口服抑毒调平液或安慰剂。收集治疗前、治疗后、停药时及停药3个月末空腹血清标本,检测细胞因子白细胞介素-4、干扰素-γ水平。另选30例年龄、性别与治疗组、对照组无明显差异的健康人作正常组。结果治疗前治疗组、对照组患者血清IFN-γ的水平及IFN-γ/IL-4明显低于正常人(p<0.05),IL-4的含量明显高于正常人(p<0.05),治疗组与对照组患者间上述各项指标比较均无显著差异(p>0.05);治疗后、停药时、停药3个月末治疗组IFN-γ、IFN-γ/IL-4的值持续增加(p<0.05),IL-4持续下降(p<0.05),而对照组无明显变化(p>0.05)。结论2型糖尿病合并慢性乙型肝炎(中度)患者其体内Th1/Th2比值失调;抑毒调平液上调血清中IFN-r的含量及IFN-γ/IL-4的比值,下调IL-4的含量,促使Th1/Th2分泌的细胞因子比值恢复平衡,至少维持治疗结束后3个月。
Objective To observe the changes of Th1/Th2 cytokines in sera of The chronic patients with hepatitis B （CHB） and type 2 diabetes mellitus （T2DM） who were treated with oral YiDuTiaoPingYe （YDTPY）. Methods 50 patients infected with hepatitis B virus （HBV） and T2DM were randomized into two group, receiving either YDTPY （T group,n =25） or Placebo（C group,n =25）. In addition, 30 health persons were chosen as normal group （N group）. Before and after treatment as well as following 3 months, serum IL -4, IFN -γ were measured with enzyme - linked immunosorbent assay （ELISA）. Results Before treatment, the serum levels of IFN - γ, IFN - γ/IL -4 were significantly higher in N group than in T group or C group（p 〈 0.05 ）, but IL -4 was significantly lower in N group. There were no significant differences between T group and C group in the parameters mentioned above. Within observing period, the serum levels of IFN -γ, IFN -γ/IL -4 maintained a sustained increase in T group com- pared with C group （p 〈 0.05 ）. Conclusion YDTPY can regulate up the serum levels of IFN - γ, IFN - γ/IL - 4, but IL- 4 appeared a contrary trend.
出处
《现代医院》
2007年第10期35-36,共2页
Modern Hospitals
