摘要
目的探讨前列腺干细胞抗原(PSCA)在前列腺癌(Pca)中的表达及临床意义。方法应用免疫组织化学方法,对PSCA蛋白在41例Pca、5例正常前列腺组织(NP)和9例前列腺增生组织(BPH)中的表达水平进行检测。结果PSCA在NP、BPH及Pca组织表达阳性率分别为60.0%、66.7%和80.5%,强阳性率分别0、11.1%和61.0%。PSCA在NP和BPH组织之间表达水平差异无显著性;Pca与NP和BPH组织的表达水平差异有显著性(P<0.05);PSCA的表达水平与Pca的临床分期和病理分级无相关性,(P>0.05)。结论PSCA在Pca有稳定的高表达,它可能成为前列腺肿瘤治疗的分子靶点。
[Objective] To explore the expression of prostate stem cell antigen （PSCA） in the prostate carcinoma and its clinical value. [Methods] Immunohistochemical method was used in detecting PSCA in 5 NP, 9 BPH and 41 Pca tissues. [Results] The positive rates of expression of PSCA in NP, BPH and prostatic adenocareinoma tissues were 60.0%, 66.7% and 80.5% respectively, and the strong positive rate of which were 0, 11.1% and 61.0% respectively. The PSCA expression level between normal prostate tissues and BPH had no statistical difference. As compared to NP and BPH tissues, the PSCA expression level of prostate cancer was significantly different. Both clinical stage and cell grade of prostatic cancer were not statistically correlated to the PSCA expression level. [ Conclusion] PSCA always has high expression in Pca and it probably becomes the potential drug molecular target during the immunotherapy of Pca.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第15期1856-1858,共3页
China Journal of Modern Medicine
基金
湖南省科技厅课题(课题编号03ssy4009)
