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鼻咽癌患者外周血中CD4^+CD25^+调节性T细胞的检测 被引量:3

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摘要 目的:探讨鼻咽癌患者外周血中CD4+CD25+调节性T(Tr)细胞的变化及临床意义。方法:采用流式细胞检测技术对47例鼻咽癌患者以及18例健康者外周血CD4+CD25+T细胞进行观察,并比较不同病期的变化情况。结果:鼻咽癌患者外周血中CD4+CD25+T细胞的比例为(4.47±2.15)%,高于正常对照组(1.70±0.84)%(P<0.05)。鼻咽癌I期外周血CD4+CD25+T细胞比例为(2.99±2)%;Ⅱ期为(3.54±1.97)%;Ⅲ期为(4.53±1.56)%,Ⅳ期为(6.53±1.73)%。Ⅰ+Ⅱ期组为(3.3±1.88)%,低于Ⅲ+Ⅳ期组的(5.53±1.88)%,两者比较差异有统计学意义(P<0.05)。结论:鼻咽癌患者外周血CD4+CD25+T细胞与鼻咽癌病变的进展有关,并对鼻咽癌病人的免疫具有抑制作用。
出处 《广西医科大学学报》 CAS 北大核心 2007年第3期379-381,共3页 Journal of Guangxi Medical University
基金 广西教育厅立项项目资助(No200510117)
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