摘要
目的:评价并与奥美拉唑比较泮托拉唑治疗反流性食管炎的疗效和安全性。方法:60例胃镜诊断的反流性食管炎患者,随机分为2组,每天分别口服泮托拉唑胶囊40mg和奥美拉唑肠溶片40mg,于治疗4周和8周后观察反酸、烧心、反食等症状的改善情况,并复查胃镜,观察镜下治愈率,详细记录不良反应。结果:治疗4周后,两组症状明显改善,症状记分较治疗前明显下降(P<0.01)。治疗4周、8周后,泮托拉唑组症状改善总有效率分别为83.3%、93.3%,对照组为76.7%、86.7%,两组比较无显著性差异(P>0.05);泮托拉唑组治愈率分别为60.0%、83.3%,奥美拉唑组为53.3%、76.7%,两组比较无显著性差异(P>0.05)。两组患者均能良好耐受,末发现严重的不良反应。不良反应率泮托拉唑组为3.3%,奥美拉唑组为6.7%,两组比较无显著性差异(P>0.05)。结论:泮托拉唑是治疗反流性食管炎安全、有效的药物。
objectlve：To compare the efficacy and safety of pantoprazole with that of omeprazole in patients with reflux esophagitis disease. Methods ：60 patients with endoscopically confirmed reflux esophagitis were enrolled. They were randomly divided into two groups. 30 patients were treated with a once-daily dose of pantoprazole 40 mg in the treatment groups. 30 patients were treated with a once-daily dose of omeprazole 40 mg in the control group, and reflux symptoms including regurgitation, heartburn and food reflux were evaluated after 4 and 8 weeks. And endoscopy was performed to study the healing rate. Results：After 4 weeks treatment ,the symptoms improved significantly, and symptom scores were greatly decreased in both groups （P〈0.01）. The total effective rate of symptom improvement was 83.3%,93.3% after 4,8 weeks in the treatment groups , and 76.7% ,86.7% in the control group.There was no difference between two groups （P〉0.05）. The healing rate was 60.0% ,83.3% after 4,8 weeks in the treatment group, and 53.3% ,76.7% in the control group.There was no difference between two groups （P〉0.05）,The rate of side effects were 3.3% in the treatment group, 6.7% in the control group.There was no difference between two groups （P〉0.05）. Conclusion：Pantoprazole is an effective and safe drug for reflux esophagitis
出处
《中国医药导报》
CAS
2007年第08S期42-43,共2页
China Medical Herald
关键词
胃食管反流病
反流性食管炎
泮托拉唑
药物治疗
. Gastroesophageal reflux disease
Reflux esophagitis
Pantoprazole
Drug therapy
