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IL-12、IFN-γ与复发性流产的相关性研究 被引量:12

Correlation between levels of IL-12 and IFN-γ and recurrent spontaneous abortion
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摘要 目的:测定复发性流产(RSA)患者血清IL-12、IFN-γ水平,探讨IL-12和IFN-γ与复发性流产发病的关系。方法:采用酶联免疫吸附法检测RSA患者30例(RSA组),血清IL-12、IFN-γ水平,并以正常早孕妇女25例(NEP组)及健康未孕妇女25例(NNP组)作为两个对照组。结果:RSA患者血清IL-12、IFN-γ水平显著高于正常早孕妇女及正常未孕妇女(P<0.05),且两者水平呈正相关性(r=0.580,P<0.01),正常早孕妇女血清IL-12、IFN-γ水平低于未孕妇女但无统计学意义(P>0.05)。复发性流产患者流产次数与血清IL-12和IFN-γ水平差异无显著性(P>0.05)。结论:IL-12和IFN-γ在复发性流产发生机制中起一定的作用。 Objective: To explore the correlation between levels of interleukin-12 (IL-12) and interferon-γ (IFN-γ) and recurrent spontaneous abortion (RSA). Methods: Thirty patients with RSA( the RSA group), twenty-five normal early pregnant women (the NEP group) and twenty-five normal non-pregnant women( the NNP group) were enrolled in this study. The serum concentrations of IL-12 and IFN-γwere determined by enzyme-linked immunosorbant assay (ELISA). Results: Levels of IL-12 and IFN-γ were significantly higher in the RSA group than in the other groups(P 〈 0.05) and there was a positive correlation between IL-12 and IFN-γ. Levels of IL-12 and IFN-γ were lower in the NEP group than in the NNP group, but there was no statistical difference( P 〉0.05). Conclusion: IL-12 and IFN-γ may play an important role in the occurrence of RSA.
出处 《山东大学学报(医学版)》 CAS 北大核心 2007年第7期702-704,共3页 Journal of Shandong University:Health Sciences
关键词 流产 习惯性 白细胞介素-12 干扰素Ⅱ型 Abortion, habitual Interleukin-12 Interferon typeⅡ
作者简介 王国华(1980-),女,硕士研究生,主要从事妇产科学的研究。 [通讯作者]左常婷(1962-),女,硕士生导师,副主任医师,主要从事妇产科学的研究。
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参考文献6

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二级参考文献9

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