摘要
目的 了解社区糖尿病视网膜病变患者黄斑水肿的患病情况。方法对上海北新泾街道社区100例（151只眼）15岁以上2型糖尿病患者进行直接检眼镜、眼底照相、超声波及相干光断层扫描（OCT）检查，并对检查结果进行统计学分析。结果实际调查对象795人，发现有糖尿病视网膜病变者215例，随机抽取100例糖尿病患者，有151只眼发生糖尿病视网膜病变，其黄斑中心凹平均厚度195．7μm；有46只眼的黄斑增厚，其中黄斑视网膜海绵样肿胀35只眼（76．1％），黄斑囊样水肿8只眼（17．4％），神经上皮层脱离3只眼（6．5％）。黄斑中心凹厚度与最佳矫正视力的负对数之间有相关性（r=0．2869，P=0．0004）。不同程度糖尿病视网膜病变者其黄斑水肿的患病情况有所不同（P=0．0003）。糖尿病黄斑水肿的发生与玻璃体后脱离情况的关联无统计学意义（P=0．472）。结论社区糖尿病视网膜病变患者中黄斑水肿患病率为37．1％。患眼的OCT图像归为三种类型：视网膜海绵样肿胀、黄斑囊样水肿及神经上皮层脱离。糖尿病视网膜病变的程度越重，发生黄斑水肿的可能性越大。糖尿病黄斑水肿与有无玻璃体后脱离无明显联系，与总胆固醇水平呈负相关。（中华腰科杂志．2007，43：626-630）
Objective To investigate the prevalence of diabetic retinopathy （ DR ） and diabetic macular edema （DME） in Beixinjing District, and analyze the image characteristics of their Optical coherence tomography（ OCT）, so as to evaluate the correlation among DME and the grade of DR as well as posterior vitreous detachment（PVD）, Methods In a prospective study, OCT was performed in 151 eyes of 100 type 2 diabetes patients with DR and 102 normal eyes as control subjects. Results 795 cases were examined, and 215 of them were diagnosed to have DR. The average thickness of macular fovea was 195.56 μm in 151 eyes from 100 random sampling. 46 eyes had macular thickening. Three characteristics were found in the images of OCT in the patients with DME： sponge-like retinal swelling in 35 eyes （76. 1% ）, macular cystoid edema in 8 eyes（ 17.4% ）, and serous retinal detachment in 3 eyes（6. 5% ）. The statistical analysis showed that there was a positive correlation between the thickness of macular fovea and negative correlation with best-corrected visual acuity （ r = 0. 2869, P = 0. 0004 ）. There was statistic significance between the severity of DR and DME （ P = 0. 0003 ）. But there was no statistic significance between DME and PVD. Conclusions The prevalence of DME is 37.1% in this district. Three type images of OCT were demonstrated in DME. The macular thickness is correlated with the severity of DR regardless of PVD. （Chin J Opbtbalmol , 2007,43：626-630 ）
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2007年第7期626-630,共5页
Chinese Journal of Ophthalmology
基金
上海市科委重点课题基金资助项目（04JC14063）
关键词
糖尿病
Ⅱ型
黄斑水肿
囊样
体层摄影术
光学相干
Diabetes mellitus,type Ⅱ
Macular edema cystoid
Tomography,optical coherence
作者简介
通讯作者：许迅，Email：drxuxun@ya}100．com．cn
